七氟醚和丙泊酚对患者术后疼痛的影响及其镇痛机制研究进展

doi:10.3969/j.issn.2095-378X.2017.02.017

外科研究与新技术 ›› 2017, Vol. 6 ›› Issue (2): 128-132.doi: 10.3969/j.issn.2095-378X.2017.02.017

七氟醚和丙泊酚对患者术后疼痛的影响及其镇痛机制研究进展

李冬(综述), 张晓庆(审校)

同济大学附属同济医院麻醉科,上海 200065

收稿日期:2017-02-21 发布日期:2017-07-21
通讯作者: 张晓庆,电子信箱:xq_820175@163.com
作者简介:李冬(1989—),男,在读硕士研究生,从事临床麻醉

Research progress on effects of sevoflurane and propofol anesthesia on postoperative pain and related analgesic mechanisms

LI Dong, ZHANG Xiaoqing

Department of Anesthesiology,Tongji Hospital Affiliated to Tongji University, Shanghai 200065,China

Received:2017-02-21 Published:2017-07-21

摘要/Abstract

摘要： 术后疼痛(postoperative pain)是指手术后发生的急性疼痛,通常为伤害性疼痛,一般持续7 d以内,是临床上常见的和需要紧急处理的疼痛。它不仅给患者造成极大的痛苦,还可引起机体各个系统的病理生理改变,并导致一系列并发症,从而影响患者的预后。为了寻求一种更为优越的维持麻醉方式,很多学者将全凭静脉麻醉维持的主要药物丙泊酚(2,6-二异丙基苯酚,propofol)和吸入麻醉维持的主要药物七氟醚(氟甲基-六氟-异丙基醚,Sevoflurane)做了一系列的对比研究。而关于七氟醚吸入维持麻醉和丙泊酚静脉维持麻醉对全麻患者术后疼痛的影响如何,经过近10年的研究仍存在着一些分歧,现对其作一综述。

关键词: 术后疼痛, 丙泊酚, 七氟醚, 镇痛机制

Abstract: Postoperative pain is an acute pain occurring after operation,usually as a nociceptive pain and lasting no more than seven days,and is a common clinical syptom that needs urgent treatment.It not only hurts patients,but also causes pathological and physiological changes in various systems of the body and leads to a series of complications,thus affecting prognosis.In order to find a superior maintenance of anesthesia,a lot of researchers have compared between propofol (a main intravenous sedative-hypnotic agent) and sevoflurane (a main inhaled anesthetics).After nearly a decade of research,disagreements still exist over the effect of sevoflurane inhalation for maintenance of anesthesia versus propofol intravenous anesthesia on postoperative pain. In this article,Published literatures were reviewed in this field,in an attempt to reveal possible underlying reasons.

Key words: Postoperative pain, Propofol, Sevoflurane, Analgesic mechanism

中图分类号:

R614.2

李冬, 张晓庆. 七氟醚和丙泊酚对患者术后疼痛的影响及其镇痛机制研究进展[J]. 外科研究与新技术, 2017, 6(2): 128-132.

LI Dong, ZHANG Xiaoqing. Research progress on effects of sevoflurane and propofol anesthesia on postoperative pain and related analgesic mechanisms[J]. Surgical Research and New Technique, 2017, 6(2): 128-132.

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七氟醚和丙泊酚对患者术后疼痛的影响及其镇痛机制研究进展

Research progress on effects of sevoflurane and propofol anesthesia on postoperative pain and related analgesic mechanisms

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