Abstract: Objective To discuss the diagnosis and treatment for stone and carcinoma of intrahepatic bile duct.Methods This article analyzed the effect of serum CA199,CEA,anemia degree,and intrahepatic bile duct stone course on diagnosis and the effect of different surgical Methods on prognosis of patients with stone and/or carcinoma of intrahepatic bile duct.Results In carcinoma + stone group,serum CA199 (71.43% vs.16.67%,P=0.001) and CEA (14.29% vs.0%,P=0.001) levels were higher than those of stone group; anemia degree was more serious (<10 g/L,66.67% vs.20.0%,P=0.001); the course of intrahepatic bile duct stone was longer (17.62 vs.11.30 years,P=0.001).The patients who received half liver resection with lymph node cleaning of hilus had a longer survival time compared with the patients who received local resection with lymph node cleaning of hilus (31.67 vs.17.4 months,P=0.042). Conclusion Observation of serum CA199,CEA,hemoglobin,and stone course in patients with intrahepatic bile duct stone may help diagnose whether intrahepatic bile duct carcinoma is combined.In addition,half liver resection with lymph node cleaning of hilus is recommended to patients with intrahepatic bile duct stone combined with intrahepatic bile duct carcinoma.

Key words: Intrahepatic bile duct stone, Intrahepatic bile duct carcinoma, CA199, Anemia, Half liver resection