粪便SDC2基因甲基化检测在结直肠肿瘤早期检测中的应用价值

doi:10.3969/j.issn.2095-378X.2020.01.003

Surgical Research and New Technique ›› 2020, Vol. 9 ›› Issue (1): 10-13.doi: 10.3969/j.issn.2095-378X.2020.01.003

• Original article • Previous Articles Next Articles

Application value of fecal SDC2 gene methylation test in early colorectal tumor diagnosis

LI Chuangkun¹, HUANG Yingfeng², ZOU Liaonan³, LI Xiaoying⁴, LUO Jie⁵, NIU Feng¹, ZHAO Risheng⁶, WANG Huaiming¹, WANG Hui¹, HUANG Rongkang¹

1. Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510620, Guangdong, China;
2. Department of General Surgery, Guangzhou 12th People's Hospital, Guangzhou 510620, Guangdong, CHina;
3. Department of Anorectal Surgery, Guandong Province Hospital of Traditional Chinese Medicine Zhuhai Branch, Zhuhai 519015, Guangdong, China;
4. Department of Spleen and Gastroenterology, Jiangmen Hospital of Traditional Chinese Medicine, Jiangmen 529000, Guangdong, China;
5. Department of Internal Medicine, Shanghai International Medical Center, Shanghai 200120, China;
6. Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong, China

Received:2020-03-03 Published:2020-09-12

Abstract

Abstract: Objective To investigate the value of fecal SDC2 gene methylation test in early colorectal tumor diagnosis. Methods Medical records data of 134 enrolled patients were collected from six hospitals from January 2018 to December 2018. The sensitivity and specificity between fecal SDC2 gene methylation test and serum carcinoembryonic antigen (CEA) test for early colorectal tumor diagnosis were compared. Results Of the 134 enrolled cases, 86 cases were without colorectal tumors, 22 cases with colorectal adenoma, and 26 cases with colorectal cancer. Fecal SDC2 gene methylation was detected positive in 45 patients and negative in 89 patients. Serum CEA was detected positive in 16 patients and negative in 118 patients. In the 26 patients with colorectal cancer, the positive rate of SDC2 gene methylation (88.46%) was higher than that of serum CEA (27.59%), indicating that the sensitivity of SDC2 gene methylation test was higher than that of serum CEA test for patients with colorectal cancer (P<0.001). In the 22 patients with colorectal adenoma, the positive rate of SDC2 gene methylation was higher than that of serum CEA (22.73% vs. 4.54%, P=0.185). Conclusion Compared with serum CEA test, fecal SDC2 gene methylation test has a higher sensitivity in the diagnosis of colorectal tumor and precancerous lesions, and its role in the early diagnosis of colorectal tumor requires to be investigated in a larger sample size.

Key words: Colorectal tumor, Methylation, SDC2 gene, Early diagnosis

CLC Number:

R656

LI Chuangkun, HUANG Yingfeng, ZOU Liaonan, LI Xiaoying, LUO Jie, NIU Feng, ZHAO Risheng, WANG Huaiming, WANG Hui, HUANG Rongkang. Application value of fecal SDC2 gene methylation test in early colorectal tumor diagnosis[J]. Surgical Research and New Technique, 2020, 9(1): 10-13.

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Application value of fecal SDC2 gene methylation test in early colorectal tumor diagnosis

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