Abstract: Objective To investigate the effects of dexmedetomidine （Dex） on inflammatory factors, plasma D-dimer （D-D）, antithrombin Ⅲ （ATⅢ）,and fibrin degradation products （FDP） in patients undergoing laparoscopic cholecystectomy （LC） under general anesthesia. Methods Ninety patients undergoing LC were randomly divided into an experimental group （n=45） and a control group （n=45） with 45 cases each by random number table method. Both groups of patients underwent LC surgery under general anesthesia. The experimental group was given 0.5 μg/kg Dex before anesthesia induction and maintained at 0.25 μg/kg/h during the operation, and the control group was given the same amount of propofol. Results Before operation, there was no significant difference in serum CRP, IL-6 and TNF-α levels between the two groups （P>0.05）. At 12 h after operation, the levels of CRP [（20.5±7.3） ng·L^-1], IL-6 [（26.7±9.5） ng·L^-1] and TNF-α [（3.08±1.64） μg·L^-1] in the experimental group were significantly lower than those in the control group [（35.7±8.6） ng·L^-1], （43.8±11.6） ng·L^-1, and [（5.29±1.86） μg·L^-1 respectively] （P<0.05）. Before operation, there was no significant difference in plasma D-D, AT Ⅲ, and FDP levels between the two groups （P>0.05）; 12 h after operation,the levels of plasma D-D [（9.40±3.69） ng·L^-1] and FDP [（11.0±4.8） μg·mL^-1] in the experimental group were significantly lower than those in the control group [（14.71±5.50） ng·L^-1] and [（16.8±5.5） μg·mL^-1 respectively] （P<0.05）.The level of AT Ⅲ in the experimental group [（89.6±9.8）%] was significantly higher than that in the control group [（77.4±10.4）%] （P<0.05）. Conclusion In the patients with LC surgery under general anesthesia, the addition of Dex is beneficial to reduce inflammation and the effect of surgery on the fibrinolytic function of patients.

Key words: General anesthesia, Laparoscopic cholecystectomy, Dexmedetomidine, Inflammatory factors