Abstract: Congenital pseudarthrosis of the tibia（CPT） is a rare tibia disease in children's orthopedics, which is prone to bone nonunion, pseudarthrosis, and lower limb deformity, and is difficult to cure. Successful treatment remains challenging for orthopedic surgeons, despite many treatments developed for this disease. In recent years, with the in-depth study of CPT, the invention of new surgical methods such as "4-in-1 fusion" and "Cross-union" of tibia and fibula, and the comprehensive use of new drugs such as bisphosphonates and bone morphogenetic proteins, the cure rate has gradually increased and the rate of refracture has reduced. The present status and progress of treatment of CPT in recent years were summarized in this paper, aiming to provide reference for clinical treatment.

Key words: Congenital pseudarthrosis of the tibia, 4 in 1 fusion, Cross-union, Tibiofibula cross fusion, Bone morphogenetic proteins