去甲斑蝥素和它的抗癌作用与机制

Abstract

Abstract: Norcantharidin (NCTD) is a demethylated derivative of cantharidin which is an anticancer active ingredient of traditional Chinese medicine,and currently used clinically as a routine anti-cancer drug in China.Distinctly,understanding the anticancer effects and molecular mechanisms of NCTD is an important key for NCTD that serves as an anticancer drug in clinic.But,NCTD’s anticancer effects and mechanisms remain to be rarely elucidated.Here,we will review the key anticancer effects of NCTD,such as inducing cell apoptosis,inhibiting cell proliferation,blocking tumor invasion and metastasis,anti-angiogenesis and/or anti-vasculogenic mimicry,and their molecular mechanisms.

Key words: Norcantharidin (NCTD), Anticancer agent, Apoptosis, Invasion, Angiogenesis, Vasculogenic mimicry

CLC Number:

R 285.5

Fan Yue-Zu, Jing Wei, Sun Jian-Jun. Norcantharidin and its anti-cancer effects and mechanisms[J]. 外科研究与新技术, 2012, 1(1): 13-18.

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Norcantharidin and its anti-cancer effects and mechanisms

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