Abstract: The research of Hyperlipidemic acute pancreatitis (HLAP) has attracted wide attention around the world, especially the pathogenic mechanism. And the microcirculatory disturbance is closely associated with the result of HLAP. Hypertriglyceridemia can change hemodynamics, damage endothelial cells and result in ischaemia-reperfusion injury. Furthermore, inflammatory mediator release plays a key role in the exacerbation of pancreatitis.

Key words: Hyperlipidemic acute pancreatitis, Microcirculatory disturbance, Mechanism