体外膜肺氧合中血液异物界面作用对凝血的影响与对策

doi:10.3969/j.issn.2095-378X.2017.02.013

Abstract

Abstract: Extracorporeal membrane oxygenation (ECMO) is a sustainable technique with gas exchange and circulation support.It is extensively used in patients who are so severe that need cardiopulmonary support.Blood-material-interface interaction (BMII) during ECMO initiates adsorption between plasma proteins and material surface,activates blood coagulation pathway,and leads to coagulopathy and complications such as bleeding and thrombosis.Systematic application of anticoagulant drugs,anti-fouling coating on material surface,and anti-clotting drug release coating can partially relieve and solve the problem of BMII.Raising new concepts and developing new techniques will help reduce BMII and improve the therapentic effects of ECMO.

Key words: Extracorporeal membrane oxygenation, Blood-material-interface interaction, Coagulation

CLC Number:

R654.1

WANG Yuliang, WANG Qi, ZHANG Yangyang. Effect and treatment of blood-material-interface interaction during extracorporeal membrane oxygenation[J]. Surgical Research and New Technique, 2017, 6(2): 113-117.

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Effect and treatment of blood-material-interface interaction during extracorporeal membrane oxygenation

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