内源性大麻素系统对慢性脑低灌注患者认知功能障碍的调控作用

Abstract

Abstract: Chronic cerebral hypoperfusion induced degeneration of nerve cells is one of the important factors in low social ability in patients with cognitive dysfunction,and is closely linked to pathology of neurodegenerative and cerebrovascular disease.Domestic and foreign researches on Endocannabinoid toxin (ECS) including G protein-coupled receptor CB1,CB2,AEA,2-AG endogenous ligand and its endogenous ligand deactivation system AEA hydrolase FAAH have shown that ECS has a neuroprotective effect of endogenous physiological regulation mediated in mammalian central nervous system,which is mainly manifested in the receptor level,deactivation system,immune responses and synaptic plasticity and so on.This article is to review the endocannabinoid system (ECS) effects on cognitive impairment in patients with chronic cerebral hypoperfusion.

Key words: Endocannabinoid system, Chronic cerebral hypoperfusion, Cognition dysfunction, Regulate and control effect

CLC Number:

R742

WU Yi-fang, YU Fei, SU Shao-hua, HAI Jian. The regulatory effects of the endocannabinoid system on cognitive dysfunction in patient with chronic cerebral hypoperfusion[J]. 外科研究与新技术, 2013, 2(1): 41-44.

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The regulatory effects of the endocannabinoid system on cognitive dysfunction in patient with chronic cerebral hypoperfusion

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[1]	. Progress in Resarch on the Protective Role of ECS in Nervous System [J]. Surgical Research and New Technique, 2014, 3(3): 212-214.
[2]	HAI Jian, SU Shao-hua, WU Yi-fang, YU Fei. Cognitive impairment and changes of neuronal plasticity in rats of chronic cerebral hypoperfusion [J]. 外科研究与新技术, 2013, 2(1): 17-20.