Abstract: Objective To investigate the efficacy of nerve block combined with pulsed radiofrequency in the treatment of postherpetic neuralgia （PHN）. Methods A total of 100 PHN patients treated from January 2022 to December 2024 were selected as research subjects and randomly divided into a nerve block group （paravertebral nerve block） and a combined treatment group （paravertebral nerve block combined with pulsed radiofrequency）, with 50 cases in each group. The effects between the two groups were compared. Results Before treatment, there was no significant difference in visual analog scale （VAS）, pain rating index （PRI）, and present pain intensity （PPI） scores between the two groups （P>0.05）. The VAS, PRI, and PPI scores of both groups were significantly reduced after treatment （7 d and 30 d） （P<0.05）, and the scores in the combined treatment group were lower than those in the nerve block group （P<0.05）. Before treatment, there were no significant differences in self-rating anxiety scale （SAS）, self-rating depression scale （SDS）, Pittsburgh sleep quality index （PSQI）, and short-form 36 （SF-36） scores between the two groups （P>0.05）. At 30 d after treatment, the SAS, SDS, PSQI, and SF-36 scores of the two groups were significantly improved （SAS, SDS, and PSQI scores were reduced, while SF-36 scores were imcreased） （P<0.05）, and the scores in the combined treatment group were significantly better than those in the nerve block group （P<0.05）. The total effective rate of treatment of the combined treatment group was significantly higher than that of the nerve block group （P<0.05）. Conclusion Nerve block combined with pulse radiofrequency in the treatment of PHN can significantly alleviate pain of patients and improve treatment efficacy, which meets clinical needs and can be popularized.

Key words: Postherpetic neuralgia, Nerve block, Pulsed radiofrequency