Abstract: to study the safety and early cognitive function with propofol combined with low-dose ketamine in children sedation during dressing change. Methods eighty case 4-9 years old pediatric patients were selected, and randomly divided into two groups(n=40). A group: ketamine 1.0mg/kg+lipid emulsion (used as control), B group: ketamine 0.5 mg/kg+propofol 0.5 mg/kg, intravenous injection before dressing change. The time for continuous sedative, the time for orientation recovery, body movement and incidence of nausea following operation. Results ketamine can be safely used for dressing change in both groups’ children. The time for continuous sedative and the time for orientation recovery in group B significant less than in group A, postoperative cognitive function showed no significant difference on 6 hours; but body movement and incidence of nausea following dressing change were significantly less in group B, comparing with group A. Conclusions propofol combined with low-doses ketamine can be safely used in pediatric dressing change, and not affect early cognitive function on six hours following dressing change and reduce the incidence of nausea.