Abstract: [Abstract] Objective To summarize the gastroscope guided the feasibility of laparoscopic surgery in the treatment of gastric stromal tumor. Methods Retrospective analysis of our hospital from 2010 March to 2014 March, clinical data of 27 cases of gastric therapy guided laparoscopic surgery stromal tumor patients in gastroscopy. Results 27 cases of gastric stromal tumor patients in the endoscopic laparoscopic successful resection, tumor resection, no residue. Surgical incision of about 3～6cm, 40～110min, operation time, postoperative recovery was smooth, without any complications. The postoperative hospital stay was 4～7d, average 5.5d. Patients were followed up for 3～36 months, no recurrence or metastasis. Conclusion Laparoscopic difficult positioning of gastric stromal tumor, surgery can be guided in electronic gastroscopy, and can make more accurate and complete resection range, avoid excessive resection of normal gastric tissue and residual tumor.