Abstract: Objective To explore the application of T/DHT in Prostate Cancer（PCa） through estimating the difference of serum total T、DHT level and ratio of T/ DHT between Benign Prostatic Hyperplasia（BPH） and Prostate Cancer（PCa）. Methods 196 cases were included in the study including 115 of BPH and 81 of PCa patients from January 2015 to June 2015. The differences of serum total T、DHT level and ratio of T/DHT between two groups were studied and analyzed to investigate the significance of T/DHT in diagnosis and treatment of PCa. Results The level of serum total T、DHT and the ratio of T/DHT were lower in BPH group than PCa group. The difference was statistically significant (p< 0.05). Conclusions T、DHT level and ratio of T/DHT may play a important role in diagnosis and treatment of PCa.

Key words: Benign prostatic hyperplasia, prostate cancer, testosterone (T), dihydrotestosterone (DHT), testosterone (T)/dihydrotestosterone (DHT)