Table of Content

28 March 2016, Volume 5 Issue 1 Previous Issue    Next Issue

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Advances in the treatment of intestinal fistulas 2016, 5 (1):  1-3.  Abstract ( 155 )   PDF (456KB) ( 647 )   Save In this paper, author reviews advances in the treatment of intestinal fistulas from classification of intestinal fistulas, anti-infection, maintenance of multiple organ functions, balance of water solution and electricity, nutritional support, and deterministic treatments ect., in order to provide a guidance treatment for intestinal fistulas. Related Articles | Metrics

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A preliminary study of the T、DHT level variant between BPH and PCa patients : A case confed study 2016, 5 (1):  4-6.  Abstract ( 169 )   PDF (479KB) ( 431 )   Save Objective To explore the application of T/DHT in Prostate Cancer（PCa） through estimating the difference of serum total T、DHT level and ratio of T/ DHT between Benign Prostatic Hyperplasia（BPH） and Prostate Cancer（PCa）. Methods 196 cases were included in the study including 115 of BPH and 81 of PCa patients from January 2015 to June 2015. The differences of serum total T、DHT level and ratio of T/DHT between two groups were studied and analyzed to investigate the significance of T/DHT in diagnosis and treatment of PCa. Results The level of serum total T、DHT and the ratio of T/DHT were lower in BPH group than PCa group. The difference was statistically significant (p< 0.05). Conclusions T、DHT level and ratio of T/DHT may play a important role in diagnosis and treatment of PCa. Related Articles | Metrics

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Prostate volume change and its clinical significance of transurethral plasma kinetic enucleation of prostate 2016, 5 (1):  7-10.  Abstract ( 130 )   PDF (1077KB) ( 467 )   Save Objective To study prostate volume change and its clinical significance of transurethral plasma kinetic enucleation of prostate. Methods The clinical data of 90 patients with hyperplasia of prostate undergoing surgical treatment in our hospital during 2010.1 to 2013.12 were retrospectively analyzed. Prostate volume and international prostate symptom score (IPSS), maximum urinary flow rate (Qmax) and residual urine (RU) of TUEB and SPP groups were compared. Results Postoperative prostate images in two groups were both close to prostate surgery capsule layers. Between preoperative and postoperative prostatic volumes in two groups, there were no statistically significant difference (P>0.05); In TUEB group, there was significant difference (P<0.001) in postoperative prostate volume to preoperative prostate volume. Similarly, in SPP group postoperative prostate volume was significantly difference(P<0.001) to preoperative prostate volume. In TUEB and SPP groups, postoperative residual gland volume accounted for about 36% of the preoperative volume, and residual prostatic volume mainly was surgical capsule. Postoperative IPSS, Qmax and RU in each group were improved (P<0.05), but there was no statistically significant difference between curative effect of the two groups(P>0.05). Conclusion Transurethral prostate enucleation by a surgical capsule, can effectively relief prostate hyperplasia symptoms in patients with lower urinary tract obstruction, and have high safety. The skill of transurethral enucleation of prostate may replace TURP as the “golden standard” in the surgical treatment of BPH in the future. References | Related Articles | Metrics

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Study on the DNA Double-Strand break repair of ATM -/- mice sertoli cells 2016, 5 (1):  11-14.  Abstract ( 122 )   PDF (2304KB) ( 272 )   Save [Abstract] Objective To Study the repair of DNA double-strand break(DSB) in ATM-/- mice sertoli cells. Methods 30 4-5wk C57 male mice were randomly divided into ATM-/- mice group and control group,of which were randomly divided into 0.1Gy X-ray irradiation(ionizing irradiation)0 min,45min,2hr,24hr,48hr groups ,immunofluorescence staining of DAPI and γ-H2Ax were done. Results After low-dose irradiation,ATM-/- mice sertoli cells have a lower repair efficiency than wild type mice germ cells. Conclusion Efficiency of DSB repair in ATM-/- mice sertoli cells is lower than that of C57 mice. References | Related Articles | Metrics

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Clinical study of laparoscopic-assisted radical right hemicolectomy and traditional laparotomy 2016, 5 (1):  15-17.  Abstract ( 102 )   PDF (525KB) ( 329 )   Save Objective:To compare the clinical effect of laparoscopic-assisted radical right hemicolectomy and traditional laparotomy. Method:46 patients of receiving the laparoscopic-assisted radical right hemicolectomy from March 2013 to March 2015 in our hospital were reviewed. At the same time period, 41 patients of receiving the laparotomy were also observed. The treatment effect for two groups was compared. Result:The incision length and intraoperative blood loss for laparoscopic group was significantly better than that of laparotomy group (P＜0.05); the operation time for laparoscopic group was longer than that of laparotomy group (P＜0.05); the removed number of lymph nodes for two group was not significantly different (P＞0.05); the evacuation time, time of leaving bed and hospitalization time for laparoscopic group was better than that of laparotomy group (P＜0.05).Conclusion: Compared with the traditional laparotomy, the laparoscopic-assisted radical right hemicolectomy can guarantee the treatment effect, have smaller incision length, fewer blood loss, faster recovery and shorten the hospitalization time. It is worthy of clinical promotion and application. References | Related Articles | Metrics

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Clinical effect of intestinal obstruction by nasal catheterization in treating senile patient postoperative adhesive intestinal obstruction 2016, 5 (1):  18-20.  Abstract ( 126 )   PDF (466KB) ( 373 )   Save Abstract Objective: To investigate the clinical effect of intestinal obstruction by nasal catheterization in the treatment of intestinal obstruction. Methods: 50 cases with postoperative adhesive intestinal obstruction in our hospital from December 2014 to June 2015 were selected as study objects. They were divided into control group and observation group according to random number table, 25 cases in each group. The observation group was given nasal catheterization and control group was given nasogastric tube decompression treatment. Compared the effective rate and adverse reaction rate of the two groups. Results: After different kinds of treatment, effective rate of observation group was obviously higher than control group, and adverse rate obviously lower than control group, the different was statistically significant (P<0.05). Conclusion: Intestinal obstruction by nasal catheterization in treating senile patient postoperative adhesive intestinal obstruction remits state of patients and has significant effect. Adverse reaction rate also lowered and it is worthy of wide application. Related Articles | Metrics

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Clinical effect observation of endoscopic mucosal resection in treating large intestine sessile colorectal polyp 2016, 5 (1):  21-22.  Abstract ( 111 )   PDF (441KB) ( 645 )   Save Abstract Objective: To investigate the clinical effect of endoscopic mucosal resection in treating large intestine sessile colorectal polyp. Methods: 86 cases with large intestine sessile colorectal polyp in our hospital from January 2014 to February 2015 were selected and divided into control group and observation group, 43 cases in each group. The control group was given endoscopic argon plasma coagulation and observation group was given endoscopic mucosal resection. Observed the clinical effect of the two groups. Results: Effect, operation safety and recurrence rate of observation group had obvious difference, the difference was statistically significant (P＜0.05). Conclusion: Endoscopic mucosal resection in treating large intestine sessile can improve curative effect and satisfaction rate, lower the recurrence rate. It has higher operation safety and is worthy of application. Related Articles | Metrics

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Application of anatomical mesh in totally extraperitoneal hernia repair under the laparoscope 2016, 5 (1):  23-25.  Abstract ( 128 )   PDF (518KB) ( 326 )   Save Objective To summarize the clinical experience in using anatomical mesh for totally extraperitoneal (TEP) hernia repair under the laparoscope in the treatment of inguinal hernia. Methods The clinical data of patients receiving the placement of anatomical mesh for the treatment of inguinal hernia by TEP procedure in our hospital from June 2011 to June 2014 were retrospectively analyzed. Results The surgery was successful in all of the 54 cases in this group without switching to other surgical procedures, the operation duration was 35~115min (unilateral 48 min, bilateral 105min on average) and blood loss was 5~50ml. In these patients, 9 cases had intraoperative peritoneal rupture causing gas to enter the abdominal cavity, and the surgery was successfully completed after Veress needle was inserted for air discharge; 1 case had postoperative pseudo-sac effusion which was absorbed after puncture; 1 case experienced postoperative temporary nerve paresthesia which recovered 1 month after the surgery. The patients stayed in the hospital for 3~6 days, an average of 3.7 days, and were followed up for 1~4 years. There was no case of chronic neuropathic pain in the groin area and no recurrent case. Conclusion TEP procedure is safe and reliable with little postoperative pain and quick recovery, and has become the preferred surgical procedure for the treatment of inguinal hernia under the laparoscope. The anatomical mesh we selected features a number of advantages, including no necessity for cutting, simple operation, compliance with anatomical structure and little sense of foreign bodies compared with flat mesh. For patients with type I and II inguinal hernia whose hernial sac diameter is less than 4cm, the mesh does not need to be fixed, and thus can reduce the use of fixation device. The disadvantage is that the mesh is relatively expensive, but it does provide a better choice for patients. References | Related Articles | Metrics

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Application effect of hip bathing of mirabilite in the severe mixed hemorrhoid after PPH surgery 2016, 5 (1):  26-27,48.  Abstract ( 126 )   PDF (522KB) ( 457 )   Save Objective:To study the treatment effect of hip bathing of mirabilite in the patients with severe mixed hemorrhoid after PPH surgery. Method:60 patients with severe mixed hemorrhoid and receiving PPH surgery from May 2014 to May 2015 in our hospital were selected. The patients were randomly divided into two groups, 30 cases each group. The common group adopted potassium permanganate; the intervention group adopted mirabilite. After one week of treatment, the incidence rate of anal swelling and anal pain degree for two groups was observed. Result:The incidence rate of anal swelling for common group was significantly higher than that of intervention group (P＜0.01); the anal pain degree for common group was significantly higher than that of intervention group (P＜0.05).Conclusion: For patients of severe mixed hemorrhoid and receiving the PPH surgery, the hip bathing of mirabilite can relieve the pain, alleviate the swelling of anorectal mucosa, improve the comfort degree, promote the recovery and improve the daily quality of life. References | Related Articles | Metrics

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Relative factors analysis of T1 esophageal carcinoma risk of lymph node metastasis 2016, 5 (1):  28-31.  Abstract ( 163 )   PDF (501KB) ( 231 )   Save [Abstracts] Background Esophagectomy is the standard procedure for esophageal carcinoma, but surgery for early esophageal carcinoma has been challenged by less invasive endoscopic approaches developing quickly. So it is definitely necessary to assess risk of lymph node metastasis before screening patients to have an operation or endoscopic therapy. Objective The aim of this study was to analysis risk factors for lymphatic metastasis in T1b esophageal squamous carcinoma and evaluate its risk. Methods Cases and pathological reports of 112 T1b esophageal squamous carcinoma were retrospectively analyzed, 80 patients(group N0) had no lymph node metastasis seen as control group and 32 patients(group N1) had lymph node metastasis seen as experimental group. Tumor specimens were reevaluated for overall submucosal layer thickness, tumor length, depth of tumor infiltration as well as lymphatic and vascular infiltration. Depth of submucosal tumor infiltration was divided in thirds (SM1, SM2, SM3) and factors influencing lymphatic metastasis were assessed. Results Univariate logistic regression analysis showed depth of tumor infiltration, tumor length and tumor differentiation were risk factors influencing lymphatic metastasis formation. Variate logistic regression analysis showed tumor differentiation was independent risk factor influencing lymphatic metastasis formation(p<0.001), and removed influence of tumor differentiation, there remaining second independent factor that remained significant was tumor infiltration(p=0.023). Conclusion Lymphatic metastasis risk of T1b esophageal squamous carcinoma is high and influencing factors is more, so esophagectomy should sequentially be the standard treatment for T1b patients prone to lymphatic metastasis. Related Articles | Metrics

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Clinical treatment analysis of PFNA in 98 cases of femoral intertrochanteric fracture with or without lateral wall fracture 2016, 5 (1):  35-37.  Abstract ( 99 )   PDF (493KB) ( 533 )   Save Objective:To study the clinical effect of PFNA in patients of femoral intertrochanteric fracture with or without lateral wall fracture. Method:98 femoral intertrochanteric fracture patients of receiving PFNA from August 2011 to August 2014 in our hospital were selected. According to the preoperative observation of CT three-dimensional reconstruction imaging, the patients were divided into Group A and Group B, 49 cases each group. Group A had lateral wall fracture while Group B did not have lateral wall fracture. The clinical efficacy for two groups was compared. Result:After treatment, the operation time and hospitalization time for Group B was significantly shorter than that of Group A; during operation, the bleeding amount of Group B was fewer than that of Group A; the partial and complete weight bearing time and healing time for Group B was better than that of Group A(P＜0.05).Conclusion: For patients of femoral intertrochanteric fracture complicated with lateral wall fracture, CT three-dimensional reconstruction technology has a higher clinical promotion and application value. References | Related Articles | Metrics

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Clinical Effect Observation of Arthroscopic Microfracture in the Repair of Full-Thickness Chondral Defects of Knee 2016, 5 (1):  41-43.  Abstract ( 120 )   PDF (495KB) ( 319 )   Save [Abstract] Objective:To explore the clinical effect of arthroscopic microfracture in the repair of full-thickness chondral defects of knee. Method:90 patients with full-thickness chondral defects of knee treated from May 2013 to April 2014 in our hospital were selected and randomly divided into control group and test group, 45 cases each group. The test group adopted the arthroscopic microfracture and control group adopted the articular debridement. The clinical effect of two groups was compared. After 6m of follow-up visits, HSS of knee function and Tegner score of athletic ability of two groups before and after treatment was compared. Result:The clinical effective rate of test group (91.1%) was higher than that of control group (71.1%) (P＜0.05); HSS of knee function and Tegner score of athletic ability of two groups after treatment was improved. However, HSS of knee function and Tegner score of athletic ability of test group was better than that of control group (P＜0.05).Conclusion: For patients with full-thickness chondral defects of knee, the arthroscopic microfracture has an obvious effect and can greatly improve the articular activity and function scores. It is worthy of clinical promotion. Related Articles | Metrics

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Granulomatosis with polyangiitis: clinical and pathologic features and review of the literature 2016, 5 (1):  44-48.  Abstract ( 123 )   PDF (1484KB) ( 579 )   Save [Abstract] Objective To explore the clicicopathologic features of granulomatosis with polyangiitis(GPA). Methods The clinical, laboratory analysis and radiologic features of one GPA case were analyzed retrospectively and the related literatures were reviewed. Results Computed tomography of the chest showed bilateral pulmonary multinodular high density shape with obscure margin, inhomogeneous density .Spicula and lobulated can be seen in surroundings, with part adhering to the pleural. Sinuses CT scanned left paranasal sinusitis. The laboratory analysis showed a positive test of anti-antineutrophil cytoplasmic antibody .The biopsy sample were got from nasal cavity operation and lung puncture. The pathological morphology presented with necrotizing granulomatous, local changes in vasculitis. Conclusion GPA is a kind of necrotizing granulomatous vasculitis, which involves respiratory, lung and kidney with low incidence and poor prognosis; The clinicians can choose biopsy in the case of laboratory and radiologic failed definitive diagnosis, for the timely diagnosis is the key of treatment. References | Related Articles | Metrics

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Recent advances of photoacoustic imaging in urologic diseases 2016, 5 (1):  49-52.  Abstract ( 125 )   PDF (572KB) ( 281 )   Save Photoacoustic imaging has the potential for real-time molecular imaging at high resolution and deep inside the tissue, using nonionizing radiation, making this technique very promising for a range of clinical applications. The fact that photoacoustic imaging systems can be made portable and compatible with existing imaging technologies like ultrasound favors clinical translation even more. The breadth of clinical applications in which photoacoustic could play a valuable role include urologic diseases. In this review, we describe the basics of photoacoustic imaging and its recent advances in urology. References | Related Articles | Metrics

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Bioinformatics applications in the pathogenesis and drug design of Alzheimer's disease 2016, 5 (1):  53-56.  Abstract ( 116 )   PDF (515KB) ( 583 )   Save Alzheimer's disease (AD) is a common neurodegenerative disease, the main clinical manifestations of it is progressive memory impairment and cognitive dysfunction. However, the molecular pathogenesis of AD is complex and unclear, is the result of various genes and cellular signaling pathway interactions. Lacking the effective treatment of AD clinically, AD has become difficulty neuroscience clinical treatment. Currently, bioinformatics in medicine is widely applied. Using it to analysis the related gene chip data, construct the related gene and cell signal transduction pathway network diagram of AD, can systematic analysis pathogenesis of AD and screen the key signaling pathway, gene and enzyme, which will provide a new perspective of the drug design and re-use and a new theoretical basis to treat AD. Related Articles | Metrics

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Potenial mechanisms of electoracupuncture in improving postoperative cognitive function 2016, 5 (1):  57-60.  Abstract ( 125 )   PDF (516KB) ( 389 )   Save Postoperative cognitive dysfunction is a common clinical phenomenon after surgery.It refers to the delaying rehabilitation of patients and the declining quality of life, even increases the disability rate and mortality rate 1 year after operation.The mechanisms,prevention and cure of POCD are not clear yet. Electroacupuncture is a new type of treatment for the combination of traditional acupuncture and modern medicine.A variety of studies have indicated that electroacupuncture can improve POCD.The article reviewed several potential mechanisms that have been reported. References | Related Articles | Metrics

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Progress in Surgical Treatment of Pelvic Organ Prolapse 2016, 5 (1):  61-65.  Abstract ( 158 )   PDF (542KB) ( 675 )   Save Pelvic organ prolapse is a kind of common gynecological diseases, including: anterior vaginal prolapse, uterine prolapse, posterior vaginal prolapse and vaginal vault prolapse. As the science and technology develop, the means of diagnosis and treatment in POP is updating constantly and getting minimally invasive. There is a discussion on the choice of different type of the POP operations. References | Related Articles | Metrics

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Nursing?Experience of?Gamma?Knife?in the Treatment of?Metastatic?Brain?Tumors?? 2016, 5 (1):  66-68,72.  Abstract ( 116 )   PDF (550KB) ( 234 )   Save [Abstract] Objective?To summarize the?nursing experience?of?gamma knife?in treatment of?patients?with?metastatic brain tumors.?Methods?Department?in May 2004 - April 2014 The?whole nursing of?2,851 patients?with?metastatic brain tumors?during?gamma knife?treatment?were conducted.?Results?Using gamma knife?treatment?through intensive care patients?Treatment of?patients were completed safely without?complications.?Conclusion??In the process of using gamma knife treatment of patients with brain metastases?Proper instruction and education?before treatment?will releasepatients’?stress?and?bring good cooperation, which is?beneficial to?track?patients’?condition closely.?Patientand careful nursing?in hospital as well as?carefulguidiance?after discharge?can improve the?the effect of gamma knife treatment. References | Related Articles | Metrics