Abstract: Abstract Objective To analyze the correlation between CT characteristics and visceral pleural invasion (VPI) in lung adenocarcinoma presented with ground glass opacity (GGO). Methods 740 GGOs diagnosed with adenocarcinoma were selected, including 84 lesions with VPI. Results Age, GGO types (pure or part solid), the largest whole diameter, the largest diameter of consolidation, the proportion of consolidation, the distance from lesions to pleura, pleural retraction, margins (smooth or nonsmooth) and shape (round/oval or irregular) were significantly associated with VPI. Multivariate logistic regression analysis showed the largest whole diameter >12mm, the largest diameter of consolidation >5mm, the distance from lesions to pleura <6mm, pleural retraction, nonsmooth margin were risk factors of VPI (OR=3.23, 4.41, 3.58, 2.21, 2.65). The area under the receiver operating curve of multivariate analysis model was 0.861. Conclusion Preoperative CT was useful in evaluating VPI for pulmonary GGO diagnosed with adenocarcinoma.

Key words: Ground glass opacity, Computed tomography, Visceral pleural invasion