早期食管癌淋巴结转移风险的相关因素分析

Abstract

Abstract: [Abstracts] Background Endoscopic technology provide a new choice for the therapy for early esophageal carcinoma, but it is Unable to complete lymph node cleaning . So it is definitely necessary to assess risk of lymph node metastasis before screening patients to have an operation or endoscopic therapy. Objective The aim of this study was to analysis risk factors for lymphatic metastasis in T1 esophageal squamous carcinoma and evaluate its risk. Methods Cases and pathological reports of 167 T1 esophageal squamous carcinoma were retrospectively analyzed, 133 patients(group N0) had no lymph node metastasis seen as control group and 34 patients(group N1) had lymph node metastasis seen as experimental group. Tumor specimens were reevaluated for overall submucosal layer thickness, tumor length, depth of tumor infiltration as well as lymphatic and vascular infiltration. Depth of submucosal tumor infiltration was divided in six layer (M1、M2、M3、SM1, SM2, SM3) and factors influencing lymphatic metastasis were assessed. Results Univariate logistic regression analysis showed depth of tumor infiltration, tumor length and tumor differentiation were risk factors influencing lymphatic metastasis formation. Variate logistic regression analysis showed depth of tumor infiltration（p=0.046）, tumor length（p=0.046） and tumor differentiation（p=0.021） were independent risk factors influencing lymphatic metastasis formation(p<0.05). Conclusion Lymphatic metastasis risk of T1 esophageal squamous carcinoma is high and influencing factors is more, so esophagectomy should sequentially be the standard treatment for T1b patients prone to lymphatic metastasis.

Key words: esophageal carcinoma, T1, lymph node, metastasis

References

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Relative factors analysis of early esophageal carcinoma risk of lymph node metastasis

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