Abstract: [Abstract] Objective：The Digital Operating Room,with multiple HD video synthesis system is important for improving quality of medical teaching and tele-surgery. ,Methods：Operating Room.Since domestic operating room video has some problems such as video resolution low,less visual angle,This paper based on the hardware structure of the FPGA,designs a system for the four HD video signals synthesis system. Results：Test results show that it runs stable and easy to operate. Conclusion：Designing and implementing multiple HD video synthesis system become a key point in construction of Digital

Key words: [Key word ]Digital operating room, HD video synthesis, FPGA