Abstract: Objective To investigate the efficacy of percutaneous transhepatic soft choledochoscopy combining with hard choledochoscopy in the treatment of complicated intrahepatic and extrahepatic bile duct stones.Method A total of 54 patients with complicated intrahepatic and extrahepatic bile duct stones were selected from our hospital from January 2016 to June 2018 and were divided into research group (n=25) and control group (n=29) according to random number table.The research group received percutaneous transhepatic soft choledochoscopy combining with hard choledochoscopy, and the control group received percutaneous transhepatic hard choledodcos copy.Operational time, intraoperative blood loss, operation frequency, length of hospital stay, stone removal rate, and complications between the two groups were compared.Results The research group had longer operation time, shorter hospital stay, less intraoperative blood loss, less complications, and higher stone removal rate (P < 0.05) than the control group, but there was no difference in the frequency of operations between the two groups (P>0.05).Conclusion Percutaneous transhepatic soft choledochoscopy combining with hard choledochoscopy for complicated intrahepatic and extrahepatic bile duct stones is effective, with shorter hospital stay, less trauma and operational blood loss, and faster recovery; thus it is worth of clinical promoting.

Key words: Fibrocholedochoscope, Hard choledochoscope, Intrahepatic and extrahepatic bile duct stones