Objective To investigate the clinical efficacy of non-thermal far-infrared irradiation combined with alginate silver ion dressing in promoting anal fistula wound healing. Methods A total of 90 patients with anal fistula who received treatment in the Department of Anorectal Surgery at our hospital from July 2023 to June 2024 were selected and randomly divided into an experimental group and two control groups （30 cases in each group）. The patients in the experimental group received treatment with non-thermal far-infrared irradiation combined with alginate silver ion dressing, those in the first control group received alginate silver ion dressing, and those in the second control group received non-thermal far-infrared irradiation. The local wound conditions （such as the degree of wound pain, bleeding and exudation, and healing condition）, overall efficacy, biomolecular indexes of wound exudate [vascular endothelial growth factor （VEGF）, matrix metalloproteinase 2 （MMP-2）, and tissue inhibitor of metalloproteinases-1 （TIMP-1）], and inflammatory factors [serum amyloid A （SAA）, interleukin 6 （IL-6）, and procalcitonin （PCT）] were compared between the three groups. Results On the 3rd, 5th, and 10th days after surgery, the visual analog scale （VAS） scores of the experimental group were significantly lower than those of the first and second control groups, the wound healing rate was significantly higher, and the wound healing period was significantly shorter （P<0.05）. The total effective rate of patients in the experimental group was significantly higher than those in the first and second control groups （P<0.05）. On the 7th day after surgery, the levels of VEGF and TIMP-1 in wound exudate in the experimental group were significantly higher than those in the first and second control groups, while the levels of MMP-2 were significantly lower （P<0.05）; the inflammatory factor levels of serum SAA, IL-6, and PCT in the experimental group were significantly lower than those in the first and second control groups （P<0.05）. Conclusion The clinical efficacy of non-thermal far-infrared irradiation combined with alginate silver ion dressing on wound healing in patients with anal fistula is significantly better than that of non-thermal far-infrared irradiation or alginate silver ion dressing alone, and it is worth clinical promotion.
LIU Minghui
,
ZHANG Yan
,
DAI Linfeng
,
HUANG Lili
,
DING Rongxia
,
LIANG Congdie
,
ZHANG Feigong
. Non-thermal far-infrared irradiation combined with alginate silver ion dressing to promote anal fistula wound healing[J]. Surgical Research and New Technique, 2026
, 15(1)
: 59
-64
.
DOI: 10.3969/j.issn.2095-378X.2026.01.014
[1] 余芳,韦瑞丽,钟荣桂,等.藻酸盐银离子敷料联合贝复新的综合护理在肛瘘术后患者创面愈合中的效果研究[J].保健文汇,2021,22(11):119-120.
[2] 韦瑞丽,余芳,叶志华,等.藻酸盐银离子敷料促进肛瘘术后创面愈合的临床效果观察[J].结直肠肛门外科, 2020, 26(5):623-626.
[3] 郭小青,孟阳,刘倩.注射用胰蛋白酶联合银离子藻酸盐抗菌敷料治疗老年脑卒中后Ⅱ期压疮的疗效[J].广东医学, 2023, 44(9):1074-1079.
[4] 彭娟,黄欣.中药热奄包联合红外线照射对膝骨性关节炎患者疼痛及功能恢复的影响[J].医疗装备, 2023, 36(16):124-126.
[5] 高翔,洪利凯,孙家忠,等.银离子藻酸盐抗菌敷料促进混合痔术后创面愈合的临床研究[J].中医药临床杂志, 2013,25(12): 1079-1080
[6] 仲超祥,张琼,姚秋菊,等.光子治疗仪照射联合藻酸盐敷料换药在肛瘘术后的应用效果[J].中国肛肠病杂志, 2016,36(5): 48-50.
[7] 覃琛媛,黄杏琳,曹婧.银离子藻酸盐敷料联合泡沫敷料与多模式健康教育在嵌甲症治疗中的应用研究[J].中国医药指南, 2019, 17(32) : 142.
[8] 黄瑞霞,刘秋江.肛瘘术后创面愈合的中医治法应用研究进展[J].中医外治杂志,2021,30(5):64-66.
[9] 马志琼,黄小瑜,何娇.肛周脓肿或肛瘘术后影响创面愈合质量的危险因素分析[J].临床误诊误治,2020,33(2): 76-80.
[10] 章波,林恒军,邱学科,等.银黄清热汤辅助治疗对高位复杂性肛瘘患者术后疼痛和创面愈合的影响[J].辽宁中医杂志, 2023, 50(5):97-100.
[11] 王永芳,石敏,伍孔菊.健瘘操联合远红外线治疗仪照射在促进自体动静脉内瘘成熟中的应用效果研究[J].生命科学仪器, 2022, 20(S01):28.
[12] Rizzo G, Rubbino F, Elangovan S, et al.Dysfunctional extracellular matrix remodeling supports perianal fistulizing Crohn's disease by a mechanoregulated activation of the epithelial-to-mesenchymal transition[J]. Cell Mol Gastroenterol Hepatol, 2023,15(3):741-764.
[13] Porwal A, Kundu GC, Bhagwat G, et al.Polyherbal formulation Anoac?H suppresses the expression of RANTES and VEGF for the management of bleeding hemorrhoids and fistula[J]. Mol Med Rep, 2021, 24(4):736.
[14] Jaiswal P, Sharma S, Pratap A, et al.Significant presence of biofilm-producing gut-derived bacteria in anal fistula of chronic duration[J]. Int Wound J, 2021, 18(4):519-524.
[15] Włodarczyk M, Włodarczyk J, Maryńczak K, et al.Role of adipose tissue hormones in pathogenesis of cryptoglandular anal fistula[J]. Int J Mol Sci, 2024, 25(3):1501.
