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Review

Research progress on role of PVAT-mediated NO/NOS in vasomotor activity in patients with sepsis

  • LI Kun ,
  • QI Ran ,
  • LIU Nanbin
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  • Department of General Surgery of Hepatobiliary and Pancreatic Surgery, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China

Received date: 2022-06-27

  Online published: 2023-05-26

Abstract

Sepsis is a serious and fatal disease, and many mechanisms are involved in its occurrence and development. Perivascular adipose tissue (PVAT), as an important participant in cardiovascular disease, is closely related to blood vessels, and can secrete a variety of active substances to participate in the changes of vasomotor activity. Nitric oxide (NO) and nitric oxide synthase (NOS) are important vasodilators. By reviewing previous literature, we explored the mechanism of PVAT-mediated NO/NOS regulation in vascular tone in sepsis, in the hope of contributing to the follow-up research and clinical practice.

Cite this article

LI Kun , QI Ran , LIU Nanbin . Research progress on role of PVAT-mediated NO/NOS in vasomotor activity in patients with sepsis[J]. Surgical Research and New Technique, 2023 , 12(1) : 60 -65 . DOI: 10.3969/j.issn.2095-378X.2023.01.016

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