脑膜瘤分子标记物的研究进展

doi:10.3969/j.issn.2095-378X.2017.03.016

摘要/Abstract

摘要： 脑膜瘤是中枢神经系统常见肿瘤,多表现为良性,手术切除后,侵袭性脑膜瘤容易复发,给临床工作造成巨大困难。近年来随着分子生物学的发展,对于侵袭性脑膜瘤及其复发机制进行较多的研究。文章从脑膜瘤信号通路、激素受体、生长因子及其受体和基质金属蛋白酶类及其组织抑制剂等方面进行综述。

关键词: 脑膜瘤, 侵袭性, 分子生物学

Abstract: Meningioma is a common tumor in central nervous system and usually benign.After surgical resection,invasive meningioma is easy to relapse,which causes great difficulties in clinical work.In recent years,invasive meningioma and its recurrence mechanism have been well studied with the development of molecular biology.In this paper,we reviewed meningioma signaling pathways,hormone receptors,growth factors and their receptors,and matrix metalloproteinases and their tissue inhibitors.

Key words: Meningioma, Invasive, Molecular biology

中图分类号:

R739.4

李斌, 王飞. 脑膜瘤分子标记物的研究进展[J]. 外科研究与新技术, 2017, 6(3): 203-208.

LI Bin, WANG Fei. Research progress on molecular markers in patients with meningioma[J]. Surgical Research and New Technique, 2017, 6(3): 203-208.

参考文献

[1] 付洛安.加强颅内脑膜瘤的临床治疗研究[J].中华神经外科疾病研究杂志,2008,7(5):385-387.
[2] Dash C,Kumar A,Doddamani RS,et al.Pediatric intraparenchymal meningioma:A review of literature[J].Neurol India,2016,64(6):1351-1354.
[3] Yun S,Koh JM,Lee KS,et al.Expression of c-MET in Invasive Meningioma[J].J Pathol Transl Med,2015,49(1):44-51.
[4] Li P,Hao S,Bi Z,et al.Methylation of Werner syndrome protein is associated with the occurrence and development of invasive meningioma via the regulation of Myc and p53 expression[J].Exp Ther Med,2015,10(2):498-502.
[5] 张喜洋,高瑞萍,石翊飒,等.右美托咪定对脑膜瘤患者磷脂肌醇3激酶/蛋白激酶B信号通路的影响[J].国际麻醉学与复苏杂志,2014,35(4):312-316.
[6] Mrachek EK,Davis D,Kleinschmidt-Demasters BK.Dual use of E-cadherin and D2-40 immunostaining in unusual meningioma subtypes[J].Am J Clin Pathol,2015,144(6):923-934.
[7] Zhou K,Wang G,Wang Y,et al.The potential involvement of E-cadherin and beta-catenins in meningioma[J].PLoS One,2010,5(6):e11231.
[8] Saydam O,Shen Y,Wurdinger T,et al.Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway[J].Mol Cell Biol,2009,29(21):5923-5940.
[9] Cordeiro AP,Da SF,Pieczarka JC,et al.Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR[J].Mol Med Rep,2009,2(3):449-454.
[10] Heuser M,Beutel G,Krauter J,et al.High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics[J].Blood,2006,108(12):3898-3905.
[11] Abliz A,Deng W,Sun R,et al.Wortmannin,PI3K/Akt signaling pathway inhibitor,attenuates thyroid injury associated with severe acute pancreatitis in rats[J].Int J Clin Exp Pathol,2015,8(11):13821-13833.
[12] Barbieri F,Bajetto A,Porcile C,et al.CXC receptor and chemokine expression in human meningioma:SDF1/CXCR4 signaling activates ERK1/2 and stimulates meningioma cell proliferation[J].Ann N Y Acad Sci,2006,1090(12):332-343.
[13] Benvenuto M,Masuelli L,De Smaele E,et al.In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors[J].Oncotarget,2016,7(8):9250-9270.
[14] Strickland MR,Gill CM,Nayyar N,et al.Targeted sequencing of SMO and AKT1 in anterior skull base meningiomas[J].J Neurosurg,2016,25(11):1-7.
[15] Gunel M.218 Meningioma driver mutations determine their anatomical site of origin[J].Neurosurgery,2016,63(Suppl 1):185.
[16] Cohen M,Kicheva A,Ribeiro A,et al.Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms[J].Nat Commun,2015,6(2):6709.
[17] Bergoglio MT,Gomez-Balaguer M,Almonacid FE,et al.Symptomatic meningioma induced by cross-sex hormone treatment in a male-to-female transsexual[J].Endocrinol Nutr,2013,60(5):264-267.
[18] 王连平,王正希,夏立丰,等.脑膜瘤中雌、孕激素受体表达及临床病理意义[J].中国医师杂志,2007,9(4):536-537.
[19] Chacko JG,Miller JL,Angtuaco EJ.Spontaneous postpartum resolution of vision loss caused by a progesterone receptor-positive tuberculum sellae meningioma[J].J Neuroophthalmol,2010,30(2):132-134.
[20] Ji Y,Rankin C,Grunberg S,et al.Double-blind phase iii randomized trial of the antiprogestin agent mifepristone in the treatment of unresectable meningioma:SWOG S9005[J].J Clin Oncol,2015,33(34):4093-4098.
[21] 张根堂,刘文涛,刘京平.脑膜瘤与AR以及MMP-2表达的相关性研究[J].中外医疗,2016,35(28):21-23.
[22] Mawrin C,Chung C,Preusser M.Biology and clinical management challenges in meningioma[J].Am Soc Clin Oncol Educ Book,2015,35(3):e106-e115.
[23] Kaynar MY,Sanus GZ,Hnimoglu H,et al.Expression of hypoxia inducible factor-1alpha in tumors of patients with glioblastoma multiforme and transitional meningioma[J].J Clin Neurosci,2008,15(9):1036-1042.
[24] 陈坚,易伟.脑膜瘤微血管密度和碱性成纤维生长因子及成纤维生长因子受体-1的表达[J].中华实验外科杂志,2005,22(6):758.
[25] Dainichi T,Moroi Y,Duan H,et al.Paraneoplastic acanthosis nigricans and silent meningioma producing transforming growth factor-alpha[J].Eur J Dermatol,2008,18(6):721-722.
[26] 张雄新.臭氧联合活血利水法治疗脑膜瘤术后脑水肿患者的效果及对血浆内皮素的影响[J].现代中西医结合杂志,2016,25(24):2691-2692.
[27] 刘迎锋,潘亚文,袁国强.良性脑膜瘤侵袭性的分子机制研究进展[J].国际神经病学神经外科学杂志,2013,40(2):191-194.
[28] Sindoni A.Somatostatin receptor-targeted radiopeptide therapy in patients with progressive unresectable meningioma[J].J Nucl Med,2016,57(10):1657.
[29] Seystahl K,Stoecklein V,Schuller U,et al.Somatostatin receptor-targeted radionuclide therapy for progressive meningioma:benefit linked to 68Ga-DOTATATE/-TOC uptake[J].Neuro Oncol,2016,18(11):1538-1547.
[30] Baxter DS,Orrego A,Rosenfeld JV,et al.An audit of immunohistochemical marker patterns in meningioma[J].J Clin Neurosci,2014,21(3):421-426.
[31] Haybaeck J,Smolle E,Schokler B,et al.The WHO grade I collagen-forming meningioma produces angiogenic substances.A new meningioma entity[J].Anticancer Res,2016,36(3):941-949.
[32] Drake WM,Grossman AB,Hutson RK.Effect of treatment with pegvisomant on meningioma growth in vivo[J].Eur J Endocrinol,2005,152(1):161-162.
[33] Petermann A,Stampnik Y,Cui Y,et al.Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells[J].J Neurooncol,2015,122(3):451-459.
[34] Huang Q,Zhao SL,Tian XY,et al.Increased co-expression of macrophage migration inhibitory factor and matrix metalloproteinase 9 is associated with tumor recurrence of meningioma[J].Int J Med Sci,2013,10(3):276-285.
[35] Rooprai HK,Martin AJ,King A,et al.Comparative gene expression profiling of ADAMs,MMPs,TIMPs,EMMPRIN,EGF-R and VEGFA in low grade meningioma[J].Int J Oncol,2016,49(6):2309-2318.
[36] Agaimy A,Buslei R,Coras R,et al.Comparative study of soft tissue perineurioma and meningioma using a five-marker immunohistochemical panel[J].Histopathology,2014,65(1):60-70.
[37] Nigim F,Esaki S,Hood M,et al.A new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus[J].Neuro Oncol,2016,18(9):1278-1287.
[38] Jiang J,Song Y,Liu N,et al.SPARC and Vav3 expression in meningioma:factors related to prognosis[J].Can J Neurol Sci,2013,40(6):814-818.
[39] Shen WW,Chen WG,Liu FZ,et al.Breast cancer cells promote osteoblastic differentiation via Sema 3A signaling pathway in vitro[J].Int J Clin Exp Pathol,2015,8(2):1584-1593.
[40] 王大鹏,沈晓黎.脑膜瘤血管新生分子机制的研究进展[J].中国微侵袭神经外科杂志,2013,18(1):46-48.
[41] Zhao Y,Pang Q,Liu M,et al.Treadmill exercise promotes neurogenesis in ischemic rat brains via caveolin-1/VEGF signaling pathways[J].Neurochem Res,2017,42(2):389-397
[42] Gao Y,Zhao Y,Pan J,et al.Treadmill exercise promotes angiogenesis in the ischemic penumbra of rat brains through caveolin-1/VEGF signaling pathways[J].Brain Res,2014,1585(11):83-90.