外周血辅助性T细胞和调节性T细胞水平的临床研究

doi:10.3969/j.issn.2095-378X.2020.03.013

外科研究与新技术 ›› 2020, Vol. 9 ›› Issue (3): 193-196.doi: 10.3969/j.issn.2095-378X.2020.03.013

外周血辅助性T细胞和调节性T细胞水平的临床研究

徐睿

上海市嘉定区牙病防治所口腔科,上海 201899

收稿日期:2020-06-05 出版日期:2020-09-28 发布日期:2021-05-13
作者简介:徐睿(1983—),女,硕士研究生,主治医师,从事临床口腔科工作;电子信箱：yuanzhen@163.com

Clinical effect of minocycline hydrochloride combined with tinidazole on chronic periodontitis and its effect on Th17 and Treg

XU rui

Department of Stomatology, Shanghai Jiading Dental Disease Prevention and Control Institute, Shanghai 201899, China

Received:2020-06-05 Online:2020-09-28 Published:2021-05-13

摘要/Abstract

摘要： 目的研究口腔治疗中外周血辅助性T细胞（Th17）和调节性T细胞（Treg）水平的影响。方法选择2018年6月—2019年6月收治的60慢性牙周炎患者作为研究对象,随机分为对照组和观察组,各30例;其中对照组患者采用盐酸米诺环素进行治疗,观察组在对照组基础上加用替硝唑进行治疗;比较两组患者的治疗有效率、牙周炎症相关指标（菌斑指数PLI、牙齿松动度MD、牙周袋深度PPD、牙周附着水平PAL和牙龈指数GI、外周血Th17与Treg的水平和不良反应发生率。结果经治疗,观察组的总有效率高达92.42%（61/66）,显著高于对照组的70.97%（44/62）,组间差异有统计学意义（P<0.05）;观察组的菌斑指数PLI、牙齿松动度MD、牙周袋深度PPD、牙周附着水平PAL、牙龈指数GI等水平显著低于对照组,组间差异有统计学意义（P<0.05）;观察组的Th17、Treg指标水平显著低于对照组,组间差异有统计学意义（P<0.05）。观察组患者不良反应发生率为6.67%（2/30）,低于对照组的10.0%（3/30）,组间对比,差异无统计学意义（P>0.05）。结论采用米诺环素联合替硝唑治疗慢性牙周炎的疗效显著,能有效改善患者的牙齿松动、疼痛、肿胀等临床症状,优化免疫功能,弱化炎症反应,且安全性良好,值得在临床推广。

关键词: Th17, Treg, 盐酸米诺环素, 替硝唑, 安全性

Abstract: Objective To study the changes of peripheral blood helper T cells （Th17） and regulatory T cells （Treg） in oral therapy. Methods Sixty patients with chronic periodontitis treated from June 2018 to June 2019 were selected and randomly divided into a control group and an observation group, with 30 cases in each group. The control group was treated with minocycline hydrochloride, while the observation group was treated with tinidazole additionally. The treatment efficiency and periodontitis-related indicators such as plaque index （PLI）, tooth looseness （MD）, periodontal pocket depth （PPD）, periodontal attachment level （PAL）, gingival index （GI）, peripheral blood Th17 and Treg levels, and incidence of adverse reactions were compared between the two groups. Results After the designed treatment, the total effective rate in the observation group was 92.42% （61/66）, which was higher than 70.97% （44/62） in the control group （P<0.05）; the PLI, MD, PPD, PAL, GI, and the levels of Th17 and Treg in the observation group were lower than those in the control group （P<0.05）. The incidence rate of adverse reactions in the observation group was 6.67% （2/30）, which was lower than 10.0% （3/30） in the control group （P>0.05）. Conclusion The clinical effect of minocycline hydrochloride combined with tinidazole on chronic periodontitis is significant. It can effectively alleviate the clinical symptoms such as tooth mobility, swelling, and pain, optimize immune function, weaken inflammatory response, and have a high safety level; therefore, it is worthy of clinical application.

Key words: Th17, Treg, Minocycline hydrochloride, Tinidazole, Safety

中图分类号:

R780.2

徐睿. 外周血辅助性T细胞和调节性T细胞水平的临床研究[J]. 外科研究与新技术, 2020, 9(3): 193-196.

XU rui. Clinical effect of minocycline hydrochloride combined with tinidazole on chronic periodontitis and its effect on Th17 and Treg[J]. Surgical Research and New Technique, 2020, 9(3): 193-196.

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外周血辅助性T细胞和调节性T细胞水平的临床研究

Clinical effect of minocycline hydrochloride combined with tinidazole on chronic periodontitis and its effect on Th17 and Treg

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