诱导性多功能干细胞在脊髓损伤干细胞治疗中的研究进展

摘要/Abstract

摘要： 2012年诺贝尔生理与医学奖颁发给Shinya Yamanaka和Sir John Gurdon后,受此风潮影响,医学领域对诱导性多功能干细胞(iPS)和重编程技术的关注激增。当iPS被认为极有可能开启细胞治疗和再生医学一个新时代时,基于iPS的细胞治疗应用于临床前首当其冲的是安全相关问题。在这篇综述中,笔者概述了iPS来源的神经干/祖细胞在脊髓损伤(SCI)的临床前研究以及其体内安全性问题,并试图讨论其临床应用策略。

关键词: 神经干/祖细胞, 诱导多潜能干细胞, 脊髓损伤, 移植

Abstract: Stimulated by the 2012 Nobel Prize in Physiology or Medicine awarded for Shinya Yamanaka and Sir John Gurdon,there is an increasing interest in the induced pluripotent stem (iPS) cells and reprograming technologies in medical science.While iPS cells are expected to lead a new era providing enormous opportunities in biomedical sciences in terms of cell therapies and regenerative medicine,safety-related concerns for iPS cell-based cell therapy should be resolved prior to the clinical application of iPS cells.In this review,the pre-clinical investigations of cell therapy for spinal cord injury (SCI) using neural stem progenitor cells derived from iPS cells,and their safety issues in vivo,are outlined.We also discussed the strategy for the first human trails of iPS cell-based cell therapy for SCI patients.

Key words: Neural stem/progenitor cell, Induced pluripotnet stem cell, Spinal cord injury, Transplantation

中图分类号:

R744

赵紫敬, 程黎明. 诱导性多功能干细胞在脊髓损伤干细胞治疗中的研究进展[J]. 外科研究与新技术, 2013, 2(1): 52-58.

ZHAO Zi-jing, CHENG Li-ming. Progression of induced pluripotent stem cells for spinal cord injury as cell transplantation therapies[J]. 外科研究与新技术, 2013, 2(1): 52-58.

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