Abstract: Objective To investigate the clinical and gastroscopic features of peptic ulcer in the elderly,and to provide a basis for relevant diagnosis and treatment.Methods A total of 187 elderly cases with peptic ulcer and 239 control cases from January 2011 to December 2016 were enrolled in this study.Their clinical manifestations and gastroscopic results were analyzed.Results The clinical symptoms of the elderly cases with peptic ulcer were not typical,showing first signs of haematemesis and melena,while the controls showed typical symptoms.Drinking and taking nonsteroids anti-inflammatory drugs(NSAIDs) were the risk factors for peptic ulcer of the elderly patients,and there were significant differences in the rates of drinking and taking NSAIDs between the two groups (P<0.001).The elderly patients reported more gastic ulcers,the controls reported more duodenal ulcers,and there were significant differences in the incidence rates of the two diseases (P<0.001).A higher rate of large ulcers (diameter>2 cm) was found in the elderly patients than in the controls,and the difference was significant (P<0.001).Conclusion The clinical symptoms of peptic ulcer are not typical in the elderly patients.There are significant differences between the elderly patients and controls in lesion site,lesion size,and risk factors.Targeted diagnosis and treatment of peptic ulcer are required for the elderly.

Key words: Elderly people, Peptic ulcer, Gastroscopy