铁死亡机制和骨肉瘤进展

doi:10.3969/j.issn.2095-378X.2025.01.001

Abstract

Abstract: Osteosarcoma is the most common primary bone tumor in children and adolescents, with a high degree of malignancy and a poor prognosis. The prevailing treatment paradigm continues to be based on a multimodality therapy of neoadjuvant chemotherapy-surgery-adjuvant chemotherapy, but the survival benefit provided by chemotherapy has remained relatively constant over the past 40 years. Ferroptosis, as a newly discovered form of cell death, has seen rapid research progress over the past decade, and targets for tumor treatment are constantly discovered. Thus, this article commenced with the proposal, developmental nodes, and underlying mechanisms of ferroptosis, then summarized the research results on ferroptosis in osteosarcoma, anticipated its developmental prospects, and highlighted the most urgent things in this field.

Key words: Ferroptosis, Osteosarcoma, Cell death, Tumor induction, Multimodality therapy

CLC Number:

R738.1

LIANG Tao, LIU Zhuochao, ZHANG Weibin. Research progress on ferroptosis mechanism and osteosarcoma[J]. Surgical Research and New Technique, 2025, 14(1): 1-8.

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Research progress on ferroptosis mechanism and osteosarcoma

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