Abstract: Objective To investigate the effect of ultrasound-guided bilateral transverse fascia plane （TFP） block on hemodynamics and stress response in patients undergoing inguinal hernia repair. Methods A total of 100 patients who underwent laparoscopic inguinal hernia repair in Gaozhou People's Hospital of Guangdong Province from December 2021 to November 2023 were selected as study subjects. They were divided into a study group and a control group by random number table method, with 50 cases in each group. The control group received general anesthesia, and the study group received combined ultrasound-guided bilateral TFP block. The two groups of patients were compared in terms of anesthesia drug dosage, postoperative hemodynamics, and the degree of pain. Results The dosages of propofol and remifentanilin in the study group were lower than those in the control group （P<0.05）. At the end of the operation, the heart rate （HR）, mean arterial pressure （MAP）, systolic blood pressure （SBP）, and diastolic blood pressure （DBP） between the two groups were not different （P>0.05）. At 2 h after operation, the MAP, HR, SBP, and DBP in the study group were lower than those in the control group （P<0.05）. There were statistically significant differences in pain scores between the two groups at different time points （2, 6, 12, and 24 h after surgery） （all P<0.001）. At postoperative 2, 6, 12, and 24 h after surgery, the pain scores of the study group were lower than those of the control group （P<0.05）. Conclusion Ultrasound-guided bilateral TFP block can effectively reduce the dose of intraoperative anesthetic drugs, relieve postoperative pain, and maintain hemodynamic stability in patients undergoing inguinal hernia repair.

Key words: Inguinal hernia repair, Transverse fascia plane block, Hemodynamics, Stress response