生物活性玻璃联合聚醚醚酮（PEEK）椎间融合器在经椎间孔入路腰椎椎间融合术中的应用效果

doi:10.3969/j.issn.2095-378X.2026.01.004

Abstract

Abstract: Objective To evaluate the efficacy of a bioactive glass （BG） and polyetheretherketone （PEEK） interbody fusion cage in transforaminal lumbar interbody fusion （TLIF） procedures. Method A retrospective analysis was performed on 174 patients who underwent TLIF surgery for lumbar degenerative diseases from January 2017 to December 2023. Patients were categorized into an autogenous bone graft （ABG） group （99 cases） and a bioactive glass group （75 cases） based on the bone graft material used. Patient demographics, surgical details, follow-up details, fusion segment balance parameters, and fusion progression images were collected. Surgical duration, intraoperative blood loss, postoperative mobilization time, hospital stay, and Oswestry Disability Index （ODI） were compared between the two groups. Pre- and post-operative intervertebral space height and lordosis angle, as well as bone graft fusion outcomes were also compared between the two groups. Results No statistically significant differences （P>0.05） were observed between the two groups in terms of surgical time, blood loss, postoperative mobilization time, or hospital stay. Pre- and post-operative ODI scores did not differ significantly between the groups （P>0.05）; however, both groups demonstrated a statistically significant reduction in ODI scores 5 d postoperatively compared to preoperative levels （P<0.05）. Both groups exhibited significant improvements in anterior and posterior disc height compared to preoperative measurements （P<0.05）, with no statistically significant difference between the two groups （P>0.05）. The lordosis angle of the fused segment improved significantly postoperatively in both groups （P<0.05）, with no statistically significant difference between the groups （P>0.05）. Postoperative follow-up revealed no cases of bone graft failure or pseudarthrosis in either group. Conclusion The combination of a PEEK interbody fusion cage with bioactive glass bone graft in lumbar spine surgery demonstrates good efficacy, significantly restoring intervertebral space height and lordosis angle in the fused segment.

Key words: Transforaminal lumbar interbody fusion, Bone graft material, Polyetheretherketone, Bioactive glass, Lumbar bone graft interbody fusion, Lumbar degenerative disease, Lumbar spinal stenosis, Lumbar disc herniation

CLC Number:

R681.5⁺3

SHEN Yeqin, LI Fuping, HAO Shuai, YU Yan. Application effect of bioactive glass combined with polyetheretherketone （PEEK） interbody fusion cage in transforaminal lumbar interbody fusion surgery[J]. Surgical Research and New Technique, 2026, 15(1): 15-20.

References

[1] 周四虎, 张卫. 腰椎椎间植骨融合应用进展[J]. 中外医学研究, 2015, 13(9): 160-162.
[2] 陈金磊, 王爽, 王昕. 经椎间孔入路腰椎椎体间融合术的研究进展[J]. 国际骨科学杂志, 2022, 43(1): 31-35.
[3] 国晓明, 朱冬承, 朱振, 等. MIS-TLIF下椎间Cage融合术和单纯椎间植骨融合术治疗单节段腰椎间盘突出症疗效对比[J]. 颈腰痛杂志, 2018, 39(2): 196-199.
[4] 陶瑞宝. 探讨后路减压固定联合椎间植骨融合应用于腰椎管狭窄[J]. 中外医疗, 2020, 39(10): 60-62.
[5] 翟正佳, 马群莹. 脊柱内镜下经后路腰椎椎体间融合术的现状与前景[J]. 外科研究与新技术, 2021, 10(4): 300-303.
[6] 李明阳, 张大鹏, 崔志栋. 椎间植骨面积对单节段腰椎后路减压椎间植骨融合效果的影响[J]. 中国骨伤, 2024, 37(8): 772-778.
[7] 周勇, 李京才. 不同椎间植骨方式生物力学研究[J]. 中国医疗前沿, 2012, 7(5): 41-43.
[8] 张有明, 高沛, 邱永龙. 椎体加椎间植骨融合治疗胸腰椎爆裂性骨折的临床效果分析[J]. 外科研究与新技术, 2015, 4(4): 245-247.
[9] 李林峰, 马文书, 胡坤然. 不同植骨材料应用于腰后路椎间植骨中的临床对比研究[J]. 粘接, 2022, 49(6): 50-54.
[10] 刘瑞端, 肖荣驰, 唐志宏, 等. 钛质与聚醚醚酮融合器用于腰椎后路减压椎间植骨融合内固定的效果比较[J]. 中国组织工程研究, 2015, 19(43): 6953-6957.
[11] 郑天友, 付裕. 腰椎椎管狭窄症治疗研究进展[J]. 国际骨科学杂志, 2024, 45(4): 251-256.
[12] 潘群龙, 俞海明, 陈志钦, 等. 腰椎退行性疾病患者骨质疏松诊疗情况[J]. 中国骨质疏松杂志, 2020, 26(12): 1820-1824.
[13] 李明, 种衍学, 宋将, 等. 腰椎椎体间融合不同手术入路及并发症[J]. 中国矫形外科杂志, 2017, 25(13): 1210-1214.
[14] 马瑞士. 经椎间孔入路腰椎椎间植骨融合术与经后路腰椎椎体间植骨融合术治疗老年退行性腰椎滑脱症患者的效果比较[J]. 中国民康医学, 2024, 36(10): 151-154.
[15] 胡炜, 阚顺利, 曹泽岗, 等. 仿生药物人工虎骨及钙剂在退行性腰椎滑脱椎间植骨融合治疗中的应用[J]. 中国组织工程研究, 2018, 22(36): 5741-5745.
[16] 杜鹏, 任磊, 赵宇, 等. rhBMP-2联合自体骨行椎间植骨融合治疗胸腰椎结核的疗效研究[J]. 颈腰痛杂志, 2022, 43(3): 377-380.
[17] 李忠海, 刘谟震, 赵彦涛,等. 三种植骨材料在腰椎后路椎间融合中的应用比较[J]. 中国骨与关节杂志, 2018, 7(3): 230-235.
[18] Noguchi H, Funayama T, Sato K, et al.A study on the effect of platelet-rich plasma (PRP) to promote bone fusion in lateral interbody fusion of the lumbar spine using artificial bone[J]. J Orthop Surg Res, 2024, 19(1): 691.
[19] Noriega DC, Ardura F, Hernández-Ramajo R, et al.Intervertebral disc repair by allogeneic mesenchymal bone marrow cells: a randomized controlled trial[J]. Transplantation, 2017, 101(8): 1945-1951.
[20] Vanichkachorn J, Peppers T, Bullard D, et al.A prospective clinical and radiographic 12-month outcome study of patients undergoing single-level anterior cervical discectomy and fusion for symptomatic cervical degenerative disc disease utilizing a novel viable allogeneic, cancellous, bone matrix (trinity evolution™) with a comparison to historical controls[J]. Eur Spine J, 2016, 25(7): 2233-2238.
[21] Xu B, Zhang H, Du L, et al.Selective retention of bone marrow stromal cells with gelatin sponge for repair of intervertebral disc defects after microendoscopic discectomy: a prospective controlled study and 2-year follow-up[J]. Biomed Res Int, 2021, 7(13):4822383.
[22] Arts MP, Wolfs JFC, Corbin TP.Porous silicon nitride spacers versus PEEK cages for anterior cervical discectomy and fusion: clinical and radiological results of a single-blinded randomized controlled trial[J]. Eur Spine J, 2017, 26(9): 2372-2379.
[23] Lin B, Yu H, Chen Z, et al.Comparison of the PEEK cage and an autologous cage made from the lumbar spinous process and laminae in posterior lumbar interbody fusion[J]. BMC Musculoskelet Disord, 2016, 17(1): 374.
[24] Yang S, Yu Y, Liu X, et al.Clinical and radiological results comparison of allograft and polyetheretherketone cage for one to two-level anterior cervical discectomy and fusion: A CONSORT-compliant article[J]. Medicine (Baltimore), 2019, 98(45): e17935.
[25] 袁冰, 韦卓. 骨缺损修复的研究进展[J]. 生物骨科材料与临床研究, 2014, 11(3): 38-41.
[26] Fernández-fairen M, Alvarado E, Torres A. Eleven-year follow-up of two cohorts of patients comparing stand-alone porous tantalum cage versus autologous bone graft and plating in anterior cervical fusions[J]. World Neurosurg, 2019, 122(2): e156-e67.
[27] Gomez-Ruiz V, Blanco JF, Villarón EM, et al.Autologous mesenchymal stem cell transplantation for spinal fusion: 10 years follow-up of a phase I/II clinical trial[J]. Stem Cell Res Ther, 2023, 14(1): 78.
[28] 张诗逸, 王宏远, 曹庆堂. 生物玻璃应用于拔牙位点保存术的临床研究进展[J]. 口腔颌面修复学杂志, 2018, 19(3): 187-191.

Application effect of bioactive glass combined with polyetheretherketone （PEEK） interbody fusion cage in transforaminal lumbar interbody fusion surgery

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 10

Recommended Articles

Metrics

Comments

[1]	XIAO Fangzhu, XU Weiyang, ZHAO Rujia. Comprison of therapetic efficacy of percutaneous transforaminal endoscopic discectomy versus conventional laminotomy for lumbar disc herniation [J]. Surgical Research and New Technique, 2026, 15(1): 10-14.
[2]	ZHANG Huayue, JIANG Miao, GUO Songming, ZHANG Yu. Acupuncture combined with massage for lumbar disc herniation： A retrospective study [J]. Surgical Research and New Technique, 2025, 14(4): 360-363.
[3]	LUO Zhiqiang, WANG Yanghua, WU Jianshun. Curative effect of percutaneous foraminoscopic extraction of nucleus pulposus on lumbar disc herniation [J]. Surgical Research and New Technique, 2025, 14(3): 243-247.
[4]	CHEN Jiyu, XU Gengtian, LI Zengyi, ZHUANG Huaiming. Percutaneous endoscopic spinal decompression for lumbar spinal stenosis [J]. Surgical Research and New Technique, 2024, 13(2): 125-129.
[5]	HONG Qing, DONG Qiu'an, GUO Songming. Therapeutic effect of traditional Chinese medicine directional penetration therapy combined with ear point nursing on lumbar disc herniation [J]. Surgical Research and New Technique, 2023, 12(4): 314-316.
[6]	ZHONG Rongwei, CHEN Jiayu, LIU Zhanliang. Clinical application of minimally invasive lumbar surgery under spinal endoscope via interlaminar approach [J]. Surgical Research and New Technique, 2023, 12(2): 86-88.
[7]	WANG Yifeng. Effect of pedicle screw implantation combined with bilateral laminectomy on lumbar function in patients with unstable lumbar spinal stenosis [J]. Surgical Research and New Technique, 2023, 12(2): 89-92.
[8]	ZHAI Zhengjia, MA Qunying. Endoscopic posterior lumbar interbody fusion： current status and prospects [J]. Surgical Research and New Technique, 2021, 10(4): 300-303.
[9]	LIU Jianxin, WANG Zheng, LI Jian. Efficacy, surgical outcome, and prognosis of patients with lumbar disc herniation after modified foraminoplasty [J]. Surgical Research and New Technique, 2020, 9(3): 166-169.
[10]	LI Yisong, WANG Qingmin, WU Zhijun, CHEN Tianshun, HU Dongping, ZHENG Qingfeng. Comparison of clinical effects of minimally invasive surgery and traditional open surgery on lumbar degenerative diseases [J]. Surgical Research and New Technique, 2017, 6(4): 253-255.