Abstract: Abstract Objective：To investigate the diagnosis value of fiberoptic ductoscopy (FDS) in nipple discharge combined with intra-duct space occupying lesions so as to improve diagnostic accuracy of the condition. Methods：The clinical data of 85 patients with nipple discharge who received FDS in our hospital from 2012.4 to 2016.6 were analyzed retrospectively, and the results were compared with the pathological examination. Result：In 85 patients with nipple discharge, 70(82.4%) cases of intra-duct space occupying lesions was found by FDS, including 10 cases of ductal breast cancer, 51 cases of papillomatosis, 9 cases of papilloma. Much performance of intra-duct space occupying lesions was hemorrhagic discharge (83.0%). The sensitivity and specificity of FDS was 90.0%, 95.0%, the coincidence rate was 94.3%. Duct grade of ductal carcinoma was usually Ⅱ~Ⅲ(80.0%). Conclusions: FDS has high diagnostic value of intra-duct space occupying lesions for nipple discharge without palpable mass, can definite location and characteristics of lesions, is helpful for early treatment.

Key words: Nipple discharge, Intra-duct space occupying lesions, Fiberoptic ductoscopy