Abstract: Objective To explore the effect of single-channel minimally invasive percutaneous nephrolithotomy plus retrograde intrarenal surgery on complex renal calculi. Methods A total of 56 complex renal calculi patients treated from January 2017 to January 2020 were selected and randomly divided into a control group and an observation group, with 28 cases in each group. The control group received multi-channel minimally invasive percutaneous nephrolithotomy; the research group received single-channel minimally invasive percutaneous nephrolithotomy and retrograde intrarenal surgery. Operation conditions, pain and comfort scores, micturition conditions, life quality, and postoperative complications of the two groups were observed. Results There were no significant differences in operation time,preoperative International Prostate Symptom Score （IPSS）, maximum flow rate （Qmax）, and life quality between the two groups （P>0.05）. After surgery, the operation conditions in the research group were better than those in the control group; after 5 h and 48 h of surgery, the pain scores of the research group were lower than those of the control group, and the comfort scores were higher; after 3 months of surgery, the IPSS and Qmax of the research group were better than those of the control group; the life quality score at discharge of the research group was higher than that of the control group; the postoperative complication rate in the research group （10.71%） was lower than that in the control group （28.57%） （P<0.05）. Conclusion The single-channel minimally invasive percutaneous nephrolithotomy combined with retrograde intrarenal surgery can shorten hospital stays, reduce postoperative pain and postoperative complication rate, and improve life quality, treatment safety, and comfort degree.

Key words: Single-channel minimally invasive percutaneous nephrolithotomy, Retrograde intrarenal surgery, Complex renal calculi