原发性开角型青光眼与24 h眼灌注压的相关研究

doi:10.3969/j.issn.2095-378X.2022.02.001

Abstract

Abstract: Objective To investigate the circadian changes of 24-hour intraocular perfusion pressure in patients with primary open-angle glaucoma （POAG） and its correlation with visual impairment. Methods Twenty-five patients with POAG treated in the Shanghai Fifth People's Hospital Affiliated to Fudan University from March 2017 to December 2021 were selected as the observation group and another 25 healthy volunteers were selected as the control group. Intraocular pressure and blood pressure were measured every 2 h from 10：00 on the first day to 8：00 on the second day, and the mean ocular perfusion pressure （MOPP）, systolic ocular perfusion pressure （SOPP）, diastolic ocular perfusion pressure （DOPP）, and their all-day, daytime, and nighttime fluctuations were calculated. The relationships of the fluctuations with mean defect （MD） and pattern standard deviation （PSD） were tested by Pearson correlation. Results The mean values of all-day, daytime, and nighttime MOPP, SOPP, and DOPP in the observation group were lower than those in the control group （all P<0.05）. The fluctuation values of MOPP, SOPP, and DOPP in the observation group at night and all day were higher than those in the control group （all P<0.05）. The fluctuation value of MOPP in the observation group at daytime was higher than that in the control group （all P<0.05）. There were no significant differences in the fluctuation values of daytime SOPP and DOPP between the observation group and the control group. The fluctuation value of all-day MOPP in the observation group had a negative correlation with MD （r=-0.802, P<0.001） and a positive correlation with PSD （r=0.722, P<0.001）. Conclusion The mean value of intraocular perfusion pressure in the observation group is lower than that in the control group, and the fluctuation ranges of intraocular perfusion pressure in whole day and at night in the observation group are greater than those in the control group. The fluctuation value of MOPP in whole day is correlated with MD and PSD. These findings suggest that low intraocular perfusion pressure and large fluctuation of intraocular perfusion pressure may be the risk factors of glaucoma.

Key words: Intraocular perfusion pressure, Primary open-angle glaucoma, Visual function

CLC Number:

CHEN Ranran, LIAO Yujie, ZHU Haohao. Study on primary open-angle glaucoma and 24-hour intraocular perfusion pressure[J]. Surgical Research and New Technique, 2022, 11(2): 77-81.

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Study on primary open-angle glaucoma and 24-hour intraocular perfusion pressure

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