Abstract: Objective To investigate the application value of laparoscopic cholecystectomy+ laparoscopic common bile duct exploration + primary duct closure (LC+LCBDE+PDC) in patients with choledocholithiasis and cholecystolithiasis. Methods From June 2020 to June 2022, 51 patients with choledocholithiasis combined with cholecystolithiasis who underwent LC+LCBDE+PDC in our hospital were selected as LCBDE group. At the same time, 29 patients with choledocholithiasis combined with cholecystolithiasis treated with endoscopic retrograde cholangiopancreatography (ERCP)+ LC were selected as ERCP group. The clinical data of the two groups were retrospectively analyzed. Results The operation time, hospital stay, and stone clearance rate in the LCBDE group were significantly better than those in the ERCP group (P<0.05), and there was no significant difference in the postoperative anal exhaust time between the two groups (P>0.05). The scores of Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), and SF-36 were not different between the two groups before treatment (P>0.05), but were all improved after treatment (P<0.05), and the scores in the LCBDE group were significantly better than those in the ERCP group (P<0.05). The incidence of complications in the LCBDE group was significantly lower than that in the ERCP group (P<0.05). Conclusion Compared with ERCP+LC, LC+LCBDE+PDC has higher efficacy and safety in patients with choledocholithiasis combined with gallbladder stones, and can better improve the negative conditions and quality of life in patients, which is worthy of clinical reference and promotion.

Key words: Choledocholithiasis, Cholecystolithiasis, Laparoscopic cholecystectomy, Endoscopic retrograde cholangiopancreatography, Laparoscopic common bile duct exploration, Primary duct closure