Abstract: Objective To observe the clinical efficacy of compound Sanhuang liquid in wound bed preparation for chronic refractory wounds （CRW） of damp-heat and blood-stasis syndrome. Methods A total of 95 patients with CRW of damp-heat and blood-stasis syndrome from January 2018 to June 2022 were selected and randomly divided into an observation group （49 cases） and a control group （46 cases） by random number table method. Both groups received basic treatment and surgical debridement. After surgery, the control group received routine surgical dressing changes, and on this basis, the observation group received wound wet dressing with compound Sanhuang liquid. Ratios of wound to healing area and depth, the proportion of patients with complete wound healing, wound healing time, wound pathogen positive rate, reoperation rate, postoperative Bates-Jensen wound assessment tool （BWAT） score, and traditional Chinese medicine syndrome efficacy evaluation were compared between the two groups of patients. Results The ratios of wound to healing area and depth and the proportion of patients with complete wound healing in the observation group were higher than those in the control group （P<0.05）. The wound healing time, wound pathogen positive rate, and reoperation rate in the observation group were lower than those in the control group （P<0.05）. The observation group had better postoperative BWAT scores and traditional Chinese medicine syndrome efficacy than the control group （P<0.05）. Conclusion The application of compound Sanhuang liquid in the wound bed preparation for CRW of damp-heat and blood-stasis syndrome can effectively promote wound repair, shorten the course of disease, reduce the incidence of wound infection, and avoid multiple surgeries, showing good clinical efficacy. It is worthy of further promotion and application.

Key words: Compound Sanhuang liquid, Damp-heat and blood-stasis syndrome, Chronic refractory wound, Wound bed preparation