Abstract: Objective To investigate the effect of the distribution of bone cement along the midline of the vertebral body on the treatment of osteoporotic vertebral compression fractures （OVCF） using percutaneous vertebroplasty. Methods This retrospective study collected the diagnosis and treatment data of 95 patients with thoracolumbar （T11-L2） OVCF admitted to Quanzhou First Hospital from March 2020 to July 2021. According to the distribution of bone cement along the midline of the vertebral body, the patients were divided into a unilateral distribution group of bone cement （n=40） and a bilateral distribution group of bone cement （n=55）. Visual analogue scores were used to evaluate pain intensity. The vertebral height and Cobb angles of patients before and after treatment were compared by imaging analysis. The Oswestry disability index （ODI） was used to assess the degree of disability in patients. Questionnaires were distributed to evaluate patients' satisfaction with treatment plans. Results Six months after surgery, the VAS scores of the bilateral distribution group of bone cement were lower than those of the unilateral distribution group of bone cement （P<0.05）. At 7 d and 6 months postoperatively, the vertebral height increased, the Cobb angle decreased, and the ODI decreased in the bilateral distribution group of bone cement compared to the unilateral distribution group of bone cement （P<0.05）. The very satisfied and total satisfaction rates of the bilateral distribution group of bone cement were higher than those of the unilateral distribution group of bone cement （P<0.05）. Conclusion The distribution of bone cement on both sides of the vertebral midline has a good effect on correcting vertebral height and Cobb angle, indicating its satisfactory clinical recovery.

Key words: Bone cement, Percutaneous vertebroplasty, Osteoporosis, Vertebral compression fracture