Abstract: [Abstract] Objective To study the expression and significance of p53, CK20 and C-erbB-2 in uroepithelium carcinoma of bladder(BUC). Methods The expression levels of p53, CK20 and C-erbB-2 in 118 cases of BUC and 21 cases of benign lesion were detected with immunohistochermical EnVision method. Results The positive expression rates of p53 was 88.1%,CK20 were 26.3%, and C-erbB-2 were 45.8% in 118 cases of BUC. The expression of p53 in BUC was significantly increased associated with the benign lesions(P<0.01). The weakly positivity rate of p53 in low grade group was significantly more strong than in high grade group (P<0.01), but the strong positivity rate was significantly more lower than in high grade group (P<0.01). The positivity rate of CK20 in the benign lesions was lower than BUC, and the positivity rate of CK20 in low grade group was significantly more lower than in high grade group (P<0.01). There was significantly difference in expression of C-erbB-2 in BUC and the benign lesion(P<0.01). The positive expression rates of C-erbB-2 was higher and more strong in high grade group than in low grade group (P<0.01). The positive expression in low grade group always was weak or located in kytoplasm. Conclusion The overexpression of p53, CK20 and C-erbB-2 protein was observed in BUC, and their positive expressions were correlated with tumor grade, diagnosis and differential diagnosis. ［Keywords］Bladdler neoplasmas; Immunohistochemistry; p53; cytokeratin20; C-erbB-2

Key words: Bladdler neoplasmas, Immunohistochemistry, p53, cytokeratin20, C-erbB-2