MiR-155和miR-21在乳腺癌分子亚型诊断中的价值

doi:10.3969/j.issn.2095-378X.2017.04.001

Abstract

Abstract: Objective To investigate the expression and clinical significance of miR-21 and miR-155 in the molecular subtypes of invasive breast cancer.Methods The clinicopathologic data of 91 cases of invasive breast cancer were retrieved.The expression levels of miR-21 and miR-155 were detected by qRT-PCR.Results The relative expression levels of miR-21 in luminal A-like,luminal B-like,HER2,and TNBC (triple-negative breast cancer) subtypes of breast cancer were 0.000±2.238,1.008±1.297,1.670±1.774 and 0.983±1.630,respectively,and the relative expression levels of miR-155 were -2.313±1.077,-1.022±1.511,-0.051±0.903 and -0.728±1.585,respectively.There were significant differences in the relative expression levels of miR-155 of luminal B-like,HER2,and TNBC subtypes versus that in luminal A-like subtype (P<0.001).Conclusion Detecting the expression levels of miR-155 in invasive breast cancer may be a new approach for guiding breast cancer patients of luminal type to undertake chemotherapy or not.

Key words: Breast cancer, Molecular subtype, miR-21, miR-155

CLC Number:

R655.8

XU Ming, XIE Yiqun, ZHU Jiahui, HUANG Bin. Value of miR-155 and miR-21 in diagnosis of molecular subtypes of breast cancer[J]. Surgical Research and New Technique, 2017, 6(4): 229-234.

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Value of miR-155 and miR-21 in diagnosis of molecular subtypes of breast cancer

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