Abstract: Objective Explore the effect of tetramethylpyrazine on protecting rabbit’s renal function after ESWL.Methods Rabbits (20,2~3 kg) were randomly divided into the experimental group (10 rabbits,20% tetramethylpyrazine,4 ml/kg,IM) and the control group (10 rabbits).We used thiopental sodium 50 mg/kg to anesthetize rabbits,then resected the right kidney and placed a silver clip on the left renal hilum to obtain nephrolithiasis animal models.ESWL was performed after 2 weeks.We measured serum creatinine,urea nitrogen and nitric oxide 1,3,5 days before and after ESWL,and executed 3 rabbits each time from each group on day 3 and 7 after ESWL.We observed the morphology and structure of the renal tissue.Results The experimental group shows no obvious elavation of serum Cr Bun NO after ESWL while the control group has a significantly increased serum Cr,Bun,NO (P<0.05); Light and Electron microscopy shows a lower tissue damage in the experimental group than in the control group.Conclusion Tetramethylpyrazine can improve renal blood flow,increase prostaglandin synthesis in kidney,reduce angiotensin and promote scavenging oxygen free radicals.Hence Tetramethylpyrazine thas a protective effect on the acute renal injury caused by ESWL.

Key words: Eswl, Renal injury, Tetramethylpyrazine