垂直束带式胃减容术改善肥胖不育雄鼠生育力模型研究

doi:10.3969/j.issn.2095-378X.2018.02.003

Surgical Research and New Technique ›› 2018, Vol. 7 ›› Issue (2): 89-92.doi: 10.3969/j.issn.2095-378X.2018.02.003

• Original article • Previous Articles Next Articles

Obesity-induced male infertility reversed by sleeve gastrectomy in a rat model

LI Jiajing¹, WANG Yanqiu², BIAN Cuidong³, WAN Xiaodong³, XIANG Jun³

1.Auxiliary Teaching Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China;
2.Department of Reproductive Medicine, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China;
3.Department of Urinary Surgery, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China

Received:2018-05-09 Online:2018-06-28 Published:2019-12-10

Abstract

Abstract: Objective Obesity is a metabolic disease and induces a variety of diseases including infertility.Sleeve gastrectomy shows encouraging Results in terms of weight loss and quality of life improvement.This study aims to determine whether sleeve gastrectomy could reverse obesity-induced fertility impairment in male SD rats.Methods After 16 weeks of a chow diet (CD) or a high-fat diet (HFD) challenge, the HFD rats were given sleeve gastrectomy or sham operation and then fed with HFD for another 8 weeks.Serum sex hormone and sperm quality in the three groups were compared.Results Sleeve gastrectomy not only decreased HFD-induced obesity, but also reversed HFD-induced increase in teratozoospermia and decreases in sperm motility and progressive motility.The expression of sex hormones increased after sleeve gastrectomy.Conclusion Sleeve gastrectomy could reverse obesity-induced fertility impairment in rats.

Key words: Sleeve gastrectomy, Model, Fertility, Obesity

CLC Number:

R699

LI Jiajing, WANG Yanqiu, BIAN Cuidong, WAN Xiaodong, XIANG Jun. Obesity-induced male infertility reversed by sleeve gastrectomy in a rat model[J]. Surgical Research and New Technique, 2018, 7(2): 89-92.

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Obesity-induced male infertility reversed by sleeve gastrectomy in a rat model

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