长链非编码RNA在胰腺癌中的作用机制与临床应用价值

doi:10.3969/j.issn.2095-378X.2018.02.012

Abstract

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers.The underlying mechanism of PDAC is not completely revealed yet.Notably, expressions of some long non-coding RNAs (lncRNAs) undergo significant changes in the initiation and progression of cancers.Recent research has demonstrated that lncRNAs have multiple biological functions in cell growth, proliferation, and differentiation.Furthermore, lncRNAs have potential values in the diagnosis, treatment, and prognostic prediction of PDAC.In this review, the molecular mechanism of lncRNAs in PDAC and the potential clinical value were elaborated.

Key words: Long non-coding RNA, Pancreatic ductal adenocarcinoma, Clinical application

CLC Number:

R735.9

ZHANG Rundong, AI Kaixing. Mechanism and clinical value of long non-coding RNA in pancreatic cancer[J]. Surgical Research and New Technique, 2018, 7(2): 122-126.

References

[1] Long J, Luo GP, Xiao ZW, et al.Cancer statistics: current diagnosis and treatment of pancreatic cancer in Shanghai, China[J].Cancer Lett, 2014,346(2):273-277.
[2] Müller S, Raulefs S, Bruns P, et al.Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer[J].Mol Cancer, 2015,14(7):94.
[3] ENCODE Project Consortium.An integrated encyclopedia of DNA elements in the human genome[J].Nature, 2012,489(7414):57-74.
[4] Derrien T, Johnson R, Bussotti G, et al.The GENCODEv7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression[J].Genome Res, 2012,22(9):1775-1789.
[5] Wu Z, Liu X, Liu L, et al .Regulation of lncRNA expression[J].Cell Mol Biol Lett, 2014,19(4):561-575.
[6] Wang KC, Chang HY.Molecular mechanisms of long noncoding RNAs[J].Molecular Cell, 2011,43(6):904-914.
[7] ørom UA, Derrien T, Beringer M, et al.Long noncoding RNAs with enhancer- like function in human cells[J].Cell, 2010,143(1):46-58.
[8] Ge X, Chen Y, Liao X, et al.Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer[J].Med On-col, 2013,30(2):588.
[9] Tahira AC, Kubrusly MS, Faria MF, et al.Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer[J].Mol Cancer. 2011,10(11):141.
[10] Li X, Deng SJ, Zhu S, et al.Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic cancer by derepressing the miR-3923/KRAS pathway[J].Oncotarget, 2016,7(5):6000-6014.
[11] Gao S, Wang P, Hua Y, et al.ROR functions as a ceRNA to regulate Nanog expression by sponging miR-145 and predicts poor prognosis in pancreatic cancer[J].Oncotarget. 2016,7(2):1608- 1618.
[12] Jiao F, Hu H, Han T, et al.Long noncoding RNA MALAT-1 enhances stem cell-like phenotypes in pancreatic cancer cells[J].Int J Mol Sci,2015,16(4):6677-6693.
[13] Fu Z, Chen C, Zhou Q, et al.LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9[J].Cancer Lett,2017,410(23):68-81.
[14] Costache MI, Ioana M, Iordache S, et al.VEGF expression in pancreatic cancer and other malignancies:A review of the literature[J].Rom J Intern Med, 2015,53(3):199-208.
[15] Bergers G, Brekken R, McMahon G, et al.Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis[J].Nat.Cell.Biol.2000,2(10):737-744.
[16] Ma C, Nong K, Zhu H, et al.H19 promotes pancreatic cancer metastasis by derepressing let-7’s suppression on its target HMGA2- mediated EMT[J].Tumor Biol,2014,35(9):9163-9169.
[17] Zheng S, Chen H, Wang Y, et al.Long non-coding RNA LOC389641 promotes progression of pancreatic ductal adenocarcinoma and increases cell invasion by regulating E-cadherin in a TNFRSF10A-related manner[J].Cancer Lett,2016,371(2):354-365.
[18] Hu H, Wang Y, Ding X, et al.Long non-coding RNA XLOC_000647 suppresses progression of pancreatic cancer and decreases epithelial-mesenchymal transition-induced cell invasion by down-regulating NLRP3[J].Mol Cancer,2018,17(1):18.
[19] Li Z, Zhao X, Zhou Y, et al.The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer[J].J Transl Med,2015,13(3):84.
[20] You L, Chang D, Du HZ, et al.Genome-wide screen identifies PVT1 as a regulator of Gemcitabine sensitivity in human pancreatic cancer cells[J]. Biochem.Biophys.Res.Commun.2011,407(1):1-6.
[21] Liu JH, Chen G, Dang YW, et al.Expression and prognostic significance of lncRNA MALAT1 in pancreatic cancer tissues[J].Asian Pac J Cancer Prev,2014,15(7):2971-2977.
[22] Ye S, Yang L, Zhao X, et al.Bioinformatics method to predict two regulation mechanism:TF-miRNA-mRNA and lncRNA-miRNA-mRNA in pancreatic cancer[J].Cell.Biochem.Biophys.2014,70(3):1849-1858.
[23] Wang Y, Li Z, Zheng S, et al.Expression profile of long non-coding RNAs in pancreatic cancer and their clinical significance as biomarkers[J].Oncotarget,2015,6(34):35684-35698.
[24] Hanna N, Ohana P, Konikoff FM, et al.Phase 1/2a, dose-escalation, safety, pharmacokinetic and preliminary efficacy study of intratumoral administration of BC-819 in patients with unresectable pancreatic cancer[J].Cancer Gene Ther,2012,19(6):374-381.
[25] Scaiewicz V, Sorin V, Fellig Y, et al.Use of H19 gene regulatory sequences in DNA-based therapy for pancreatic cancer[J].J Oncol,2010,3(12):178-174.
[26] Sorin V, Ohana P, Gallula J, et al.H19-promoter-targeted therapy combined with gemcitabine in the treatment of pancreatic cancer[J].ISRN Oncol,2012,2(6):351-750.
[27] Wang CJ, Shi SB, Tian J, et al.lncRNA MALAT1, HOTTIP and PVT1 as predictors for predicting the efficacy of GEM based chemotherapy in first-line treatment of pancreatic cancer patients[J].Oncotarget 2017,8(56):95108-95115.
[28] Song J, Xu Q, Zhang H, et al.Five key lncRNAs considered as prognostic targets for predicting pancreatic ductal adenocarcinoma[J].J Cell Biochem.2018,119(6):4559-4569.
[29] Huang X, Ta N, Zhang Y, et al.Microarray analysis of the expression profile of long non-coding RNAs indicates lncRNA RP11-263F15.1 as a biomarker for diagnosis and prognostic prediction of pancreatic ductal adenocarcinoma[J].J Cancer,2017,8(14):2740-2755.
[30] Chen YC, Liu LC, Ye HY, et al.EZH2 promotes migration and invasion of triple-negative breast cancer cells via regulating TIMP2-MMP-2/-9 pathway[J].Am J Cancer Res,2018,8(3):422-434.
[31] Cai H, Yao J, An Y, et al.LncRNA HOTAIR acts a competing endogenous RNA to control the expression of notch3 via sponging miR-613 in pancreatic cancer[J].Oncotarget,2017,8(20):32905-32917.
[32] Cai H, An Y, Chen X, et al.Epigenetic inhibition of miR-663b by long non-coding RNA HOTAIR promotes pancreatic cancer cell proliferation via up-regulation of insulin-like growth factor 2[J].Oncotarget,2016,7(52):86857-86870.
[33] Li CH, Xiao Z, Tong JH, et al.EZH2 coupled with HOTAIR to silence microRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma[J].Int J Cancer,2017,140(1):120-129.
[34] Jiang Y, Li Z, Zheng S, et al.The long non-coding RNA HOTAIR affects the radiosensitivity of pancreatic ductal adenocarcinoma by regulating the expression of Wnt inhibitory factor 1[J].Tumor Biol,2016,37(3):3957-3967.
[35] Ma L, Tian X, Wang F, et al.The long noncoding RNA H19 promotes cell proliferation via E2F-1 in pancreatic ductal adenocarcinoma[J].Cancer Biol Ther,2016,17(10):1051-1061.
[36] Zhao L, Kong HR, Sun HW, et al.LncRNA-PVT1 promotes pancreatic cancer cells proliferation and migration through acting as a molecular sponge to regulate miR-448[J].J.Cell.Physiol.,2018,233(5):4044-4055.
[37] Zhang M, Zhao Y, Zhang Y, et al.LncRNA UCA1 promotes migration and invasion in pancreatic cancer cells via the Hippo pathway[J].Biochim Biophys Acta,2018,1864(5 Pt A):1770-1782.
[38] Zhou Y, Chen Y, Ding W, et al.LncRNA UCA1 impacts cell proliferation, invasion, and migration of pancreatic cancer through regulating miR-96/FOXO3[J].IUBMB Life,2018,70(4):276-290.
[39] Sun Z, Zhang B, Cui T.Long non-coding RNA XIST exerts oncogenic functions in pancreatic cancer via miR-34a-5p[J].Oncol Rep,2018,39(4):1591-1600.
[40] Wei W, Liu Y, Lu YB, et al.LncRNA XIST promotes pancreatic cancer proliferation through miR-133a/EGFR[J].J Cell Biochem,2017,118(10):3349-3358.
[41] Lian Y, Xiao C, Yan C, et al.Knockdown of pseudogene derived from lncRNA DUXAP10 inhibits cell proliferation, migration, invasion, and promotes apoptosis in pancreatic cancer[J].J Cell Biochem,2018,119(4):3671-3682.
[42] Zhao L, Sun HW, Kong HR, et al.The lncrna-TUG1/EZH2 axis promotes pancreatic cancer cell proliferation, migration and EMT phenotype formation through sponging mir-382[J].Cell.Physiol.Biochem.,2017,42(6):2145-2158.
[43] Li CG, Zhao ZM, Zhou ZP, et al.Linc-ROR confers gemcitabine resistance to pancreatic cancer cells via inducing autophagy and modulating the miR-124/PTBP1/PKM2 axis[J].Cancer Chemoth Pharm,2016,78(6):1199-1207.
[44] Gao ZQ, Wang JF, Chen DH, et al.Long non-coding RNA GAS5 antagonizes the chemoresistance of pancreatic cancer cells through down-regulation of miR-181c-5p[J].Biomed.Pharmcother,2018,97:809-817.

Mechanism and clinical value of long non-coding RNA in pancreatic cancer

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