Abstract: Objective To explore the application value of targeted nursing in patients with thyroid nodules undergoing ultrasound-guided fine needle aspiration biopsy （US-FNAB）. Methods A total of 206 patients with thyroid nodules undergoing US-FNAB examination from March 2018 to December 2019 were selected. They were divided into a control group （n=103） and an observation group （n=103） according to the random number table method. Routine nursing intervention was implemented to the control group, and targeted nursing to the observation group. Patients' mental state score, comfort score, success rate of first puncture, and incidence rate of complications between the two groups were compared and analyzed. Results The SDS and SAS scores of the two groups after nursing were significantly lower than those before nursing, and the scores of the observation group were lower than those of the control group （P<0.05）. The dimensional scores of comfort after nursing of the observation group were higher than those of the control group （P<0.05）. The success rate of first puncture of the observation group was 96.12%, which was higher than that of the control group （84.47%）. The incidence rate of complications of the observation group （2.91%） was lower than that of the control group （10.68%）. Conclusion Applying targeted nursing in patients with thyroid nodules undergoing US-FNAB examination can help improve their mental state, reduce the incidence of complications, increase physical and mental comfort and the success rate of first puncture, which is worthy of promotion.

Key words: Ultrasound-guided, Thyroid nodules, Fine needle aspiration biopsy, Targeted nursing