Abstract: Objective To investigate the feasibility of low-temperature plasma radiofrequency ablation in the surgical treatment of chronic rhinosinusitis with nasal polyps （CRSwNP）. Methods From January 2018 to June 2021, 48 patients with CRSwNP who met the inclusion criteria （experimental group） underwent cryogenic plasma radiofrequency ablation-assisted nasal endoscopic surgery, and another 44 patients underwent functional endoscopic sinus surgery （FESS） at the same time. Intraoperative blood loss volume, preoperative and postoperative visual analogue scale （VAS） score, Lund-Kennedy total score, Lund-Mackay score, and SNOT-20 score were compared between the two groups. Results The amount of intraoperative blood loss in the experimental group was less than that in the control group （P<0.01）. The VAS score of the experimental group was lower than that of the control group 3 months after surgery （P<0.05）, suggesting less postoperative pain in the experimental group. The Lund-Kennedy score of the experimental group was lower than that of the control group 6 months and 1 year after surgery （P<0.01）, suggesting better disease control in the experimental group. There was no significant difference between the two groups in the Lund Mackay score 3 months after surgery （P=0.373）, suggesting similar postoperative imaging changes. The SNOT score was not different between the two groups before surgery and 1 year after surgery, but was higher in the experimental group than in the control group 3 months after surgery. Conclusion Low-temperature plasma radiofrequency ablation is effective and safe in the nasal endoscopic treatment of CRSwNP, which can achieve the effect of traditional surgery, with less intraoperative bleeding, less postoperative pain, and better long-term efficacy 6 months and 1 year after surgery than FESS.

Key words: Low-temperature plasma radiofrequency Ablation, Chronic rhinosinusitis with nasal polyps, Functional endoscopic sinus surgery