Abstract: In clinical practice, high-dose vitamin C is used for septic patients to play roles in antioxidant, immunomodulation, and improvement of vascular endothelial function. This article reported a septic patient treated with high-dose vitamin C, which affected the test results of venous blood glucose, and summarized nursing critical thinking. Although the patient ended up with a poor outcome, summarizing nursing management experience would improve the nursing critical thinking for severe patients, and play a feedforward control, so as to positively and effectively improve nursing quality.

Key words: Sepsis, Vitamin C, Point-of-care testing, Blood glucose, Critical values