Abstract: Abstract Objective：To explore the clinical effect and complications of minimally percutaneous nephrolithotomy(mPCNL) with holmium laser on the treatment of complex nephritic stone. Methods：320 patients with complex nephritic stone were treated by mPCNL with holmium laser (Group A, n=160) and open renal lithotomy(Group B, n=160). The operation related indicators, stone clearance rate, degree of postoperative pain and complications between two groups were comparatively analyzed. Result：Compared with Group B, group A, the operation time, postoperative activity time and hospitalization time in Group A were significantly shortened, the intraoperative blood loss was also reduced(P<0.05). The stone clearance rate in Group A were 92.5% and 80.6% in Group B , respectively (P<0.05). The proportion of Ⅱ,Ⅲ pain was 20.6% in Group A, which was significantly lower than 38.1% in Group B(P<0.05). The incidence of bleeding, incision infection, urinary fistula and renal colic in Group A were significantly lower than those in Group B(P<0.05). Conclusions: mPCNL with holmium laser for the treatment of complex nephritic stone can effectively shorten the operation time, reduce postoperative pain and complications, improve the stone clearance rate.

Key words: Complex nephritic stone, Percutaneous nephrolithotomy, Holmium laser, Open renal lithotomy, Complications