Table of Content

28 September 2015, Volume 4 Issue 3 Previous Issue    Next Issue

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Recent progress in stem cells mediated cardiac regeneration 2015, 4 (3):  141-144.  Abstract ( 120 )   PDF (1253KB) ( 552 )   Save Research on stem cell and myocardial regeneration is still in its primary stage, with sporadic clinical reports in recent years. In this paper, we reviewed the researches in field of stem cell and myocardial regeneration, analyze the function of stem cells in this process, and summerize and envision the future of stem cells application during myocardial regeneration. References | Related Articles | Metrics

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The value of procalcitonin monitoring in early diagnosis and therapy of postoperative septic shock of upper urinary tract stones surgery 2015, 4 (3):  145-148.  Abstract ( 120 )   PDF (1096KB) ( 317 )   Save [Abstract] Objective To explore the value of procalcitonin monitoring in the early diagnosis and prognosis of postoperative septic shock of upper urinary tract stones endoscopic surgery. Methods From Jun 2012 to Dec 2013, 1027 patients undergoing minimally invasive percutaneous nephrolithotomy lithotomy or ureterscopy lithotripsy were prospective studied, the clinical data of patients with postoperative septic shock were analyzed. Procalcitonin, routine blood and blood biochemical indexes were detected at postoperative 4 h and 8 h. Useing PCT≥10ng/ml at 4 h after surgery as a threshold. Choosing the third generation cephalosporins or carbapenems at the early stage and taking active anti-shock treatmen. According to the results of bacterial culture, useing low-level antibiotics when PCT continues to decrease to < 2 ng/m at postoperative 48h, also, to strengthen support for treatment in patients with higher PCT level. Results Septic shock occurred in 7 cases, and 6 cases of septic shock in 12 patients whose PCT≥10ng/ml at postoperative 4h, PCT has a higher diagnostic sensitivity (85.7%) and specificity (99.4%) than c-reactive protein and white blood cells. PCT 27.8±18.4 ng/ml at postoperative 4 h and PCT 42.2±29.7 ng/ml at postoperative 48h, the difference is statistically significant（P＜0.05）. All cases were improved and discharged after active treatment according to the above principles when PCT decrease to ＜2 ng/ml on postoperative 8.4±4.2 d. The antibiotics use density and hospital stay of patients with higher PCT are stronger and longer than other patients. Conclution The monitoring of PCT has significant value in the early diagnosis and prognosis of postoperative septic shock of upper urinary tract stones surgery. Actively treating in earlier period and adjusting the dosage according to PCT level is beneficial to the outcome of septicshock. References | Related Articles | Metrics

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Analysis on the clinical effect and complications of minimally percutaneous nephrolithotomy with holmium laser on the treatment of complex nephritic stone 2015, 4 (3):  149-152.  Abstract ( 124 )   PDF (1236KB) ( 283 )   Save Abstract Objective：To explore the clinical effect and complications of minimally percutaneous nephrolithotomy(mPCNL) with holmium laser on the treatment of complex nephritic stone. Methods：320 patients with complex nephritic stone were treated by mPCNL with holmium laser (Group A, n=160) and open renal lithotomy(Group B, n=160). The operation related indicators, stone clearance rate, degree of postoperative pain and complications between two groups were comparatively analyzed. Result：Compared with Group B, group A, the operation time, postoperative activity time and hospitalization time in Group A were significantly shortened, the intraoperative blood loss was also reduced(P<0.05). The stone clearance rate in Group A were 92.5% and 80.6% in Group B , respectively (P<0.05). The proportion of Ⅱ,Ⅲ pain was 20.6% in Group A, which was significantly lower than 38.1% in Group B(P<0.05). The incidence of bleeding, incision infection, urinary fistula and renal colic in Group A were significantly lower than those in Group B(P<0.05). Conclusions: mPCNL with holmium laser for the treatment of complex nephritic stone can effectively shorten the operation time, reduce postoperative pain and complications, improve the stone clearance rate. References | Related Articles | Metrics

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The expression of CXCR4 and its role in clinicopathological prognostic in colon cancer. 2015, 4 (3):  153-157.  Abstract ( 121 )   PDF (3414KB) ( 257 )   Save [Abstract] Objective To analyze chemokine receptor 4 (chemokine receptor4, CXCR4) expression in colon cancer its relationship with clinicopathological features and prognosis. Methods The expressions of CXCR4 protein were probed by immunohistochemical staining in 98 specimens of colon cancer and 23 specimens of paracancerous from second Affiliated Hospital of Nantong University and its relationship with clinicopathological features and prognosis was then analyzed．Results The positive rate of CXCR4 expression in the colon cancer group (72.0%, 36/50) was significantly higher than in paracancerous normal tissue group (10%, 1/10) (P <0.05). The CXCR4 expression in colon cancer patients with different gender, age, tumor location, tumor size, histological was no significant difference (P> 0.05). However，the significant upregulation of CXCR4 expression in invasion of colon serosa group，lymph node metastasis group, and high TNM stage groups with respect to others were found(P <0.05). Conclusions The protein expression of CXCR4 was up-regulated in the colon cancer and is related to colon cancer malignancy and prognosis, which indicate CXCR4 exert its function on the development of the colon cancer. [Key words] Colon cancer; CXCR4; Immunohistochemistry References | Related Articles | Metrics

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Bithionol inhibit proliferation and induce apoptosis in glioma cell U251: a in vitro study 2015, 4 (3):  158-162.  Abstract ( 90 )   PDF (1700KB) ( 136 )   Save Objective To observe the anti-tumor activity of anti-parasite drug Bithionol and investigate the possible mechanism. Methods The viability of glioma cells was measured by CCK8 assay. The cell apoptosis was assayed by flow cytometry and Hoechst33258. Apoptosis-related proteinexpressions of Caspase 3/Cleaved caspase 3,PARP/Cleaved PARP were determined by Western blotting. The level of JNK-P-JNK induced by Bithionol was measuredby Western blotting with or without the treatment of JNK specific inhibitor SP600125.Results After treatment of Bithionol for 24 hours,the growth of glioma cell U251,U87were significantly inhibited in dose-dependent manner(P<0.05); and Bithionol increased U251 cell apoptosis alsoin dose-dependent manner (P< 0. 05). Compared with the control group, the levels of Caspase 3/Cleaved caspase 3,PARP/Cleaved PARPwere significantlyincreased in Bithinol treatment group(P<0. 05). JNK was activated in the U251 cells exposed to Bithinol and the phosphorylation of JNKalso increased. This activation of apoptosis could be reversed by the pre-treatment of SP600125. Conclusion Bithinol may induceapoptosis in glioma cell and the mechanism may be related to the activation of JNK-P-JNK signaling pathway. Related Articles | Metrics

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Comparison of transforaminal endoscopic spine system and open lumbar discectomy for treatment of diabetes patient lumbar disc protrusion 2015, 4 (3):  169-171.  Abstract ( 145 )   PDF (1183KB) ( 455 )   Save Objectives To evaluated the effect of transforaminal endoscopic spine system (TESSYS) and open lumbar discectomy for treatment of diabetes patient lumbar disc protrusion. Methods 35 diabetes patient with lumbar disc protrusion were studied. TESSYS and open lumbar discectomy for treatment of diabetes patient lumbar disc protrusion. Between before the operation and after the operation, VAS、ODI for the leg pain were analysis. Results After discectomy, 35 patients leg pains were relieved significantly. Two groups of patients with leg pain visual analogue scale (VAS) before operation were 7.7±1.6,7.9±1.5. After one month 3.5±0.9,3.3±1.4 were recording, 6 months after the treatment was 2.9±0.7,2.7±1.5. There was no significant difference between the two groups(p>0.05). Two groups of patients with leg pain and Oswestry disability index (ODI) before operation were 65.3±15.1,71.5±14.6. After one month, there were 16.8±7.9,17.1±8.5, 6 months after the treatment was 15.8±5.6,15.5±6.3.There was no significant difference between the two groups(p>0.05). Conclusion The TESSYS and open lumbar discectomy in the treatment of diabetes patients with lumbar disc protrusion can achieve satisfactory effect. References | Related Articles | Metrics

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Clinical study of two kinds fixation in treating pediatric extension-type supracondylar fracture of humerus 2015, 4 (3):  172-175.  Abstract ( 132 )   PDF (1241KB) ( 419 )   Save Abstract Objective: To investigate the clinical effect of different fixation method in treating pediatric extension-type supracondylar fracture of humerus. Methods: 48 cases of pediatric extension-type supracondylar fracture of humerus in our hospital from February 2013 to February 2014 were selected and they were divided into K-wire group and splint group, 24 cases in each group. K-wire group was given closed reduction and percutaneous K-wires fixation, splint group was given maneuver reposition and external fixation of small splints. Compared the fracture displacement situation, motor function of limbs after 3 months, postoperative morbidity rate of the two groups. Results: Occurrence rate of fracture displacement of K-wire group was obviously larger than splint group (P<0.01), the difference was statistically significant. Mild displacement, McIntyreⅢa and McIntyreⅢb occurrence rate of splint group was obviously higher than K-wire group (P<0.01), the difference was statistically significant. Excellent cases of K-wire group was obviously higher than control group (P<0.01), the difference was statistically significant. Adverse reaction rate of K-wire group was obviously lower than control group(P<0.01), the difference was statistically significant. Conclusion: K-wire fixation in treating pediatric extension-type supracondylar fracture of humerus has mild displacement, quicker function recovery, lower complication incidence rate and should be chosen preferentially. References | Related Articles | Metrics

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Application analysis of remifentanil on fast tracking cardiac anesthesia 2015, 4 (3):  176-178.  Abstract ( 114 )   PDF (1256KB) ( 291 )   Save Abstract Objective: To investigate the clinic effect of remifentanil on fast tracking cardiac anesthesia. Methods: 120 cases in our hospital from May 2014 to May 2015 were selected as study objects. They were divided into control group and observation group, 60 cases in each group. The control group was given fentanyl combined with propofol. The observation group was given remifentanil and propofol. Compared the hemodynamics, ICU observation time, extubation time, hospital stays of the two groups and clinic effect of the two groups. Results: MAP and HR post-anesthesia of the two groups was obviously lower than before-anesthesia. Decreased degree of control group was obviously greater than observation group. ICU observation time, extubation time, hospital stays of observation group was obviously shorter than control group, the difference was statistically significant (p<0.05). Conclusion: Application of remifentanil on fast tracking cardiac anesthesia has significant clinic effect. Hemodynamics is more stable and can shorten the ICU observation time, extubation time and hospital stay. It is worthy of wide application. References | Related Articles | Metrics

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Pneumonectomy with intrapericardial ligation of the pulmonary artery and vein: analysis of 41 patients with advanced central type lung cancer 2015, 4 (3):  182-183.  Abstract ( 147 )   PDF (1146KB) ( 374 )   Save Abstract: Objective To evaluate the clinical outcomes of pneumonectomy with intrapericardial ligation of the pulmonary artery and vein in patients with advanced lung cancer. Methods The clinical data of 41 cases of pulmonary resection in the treatment of patients with pulmonary resection were retrospectively analyzed. Results The incidence of postoperative complications was 26.82%, 1, 3, 5 year survival rates were 67.50%, 22.50%, 10%. Conclusion Pneumonectomy with intrapericardial ligation of the pulmonary artery and vein can extend the resection range and increase the resection rate of advanced lung cancer, as well as improve the postoperative survival. References | Related Articles | Metrics

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The treatment and diagnosis of re-expansion pulmonary edema 2015, 4 (3):  184-185.  Abstract ( 136 )   PDF (1149KB) ( 280 )   Save 目的 探讨复张性肺水肿（RPE）的预防、诊断及治疗。 方法 回顾性分析12例复张性肺水肿患者的临床资料。结果 治愈11例，死亡1例，死亡原因为急性呼吸窘迫综合征（ARDS）并发全身多器官功能衰竭（MOF）。结论 复张性肺水肿（RPE）是肺复张过程中少见而严重的并发症，重在预防和早期的诊断治疗。 Related Articles | Metrics

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Diagnosis and treatment of acute rupture bleeding of primary liver cancer (4 cases reported) 2015, 4 (3):  186-188.  Abstract ( 100 )   PDF (1203KB) ( 401 )   Save This paper analyzes the spontaneous rupture hemorrhage 4 cases of primary liver cancer cases. Prompt and timely surgical resection plus a large amount of distilled water thoroughly wash may have certain help to extend the postoperative survival time. In addition, other related treatment measures are discussed. Related Articles | Metrics

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Clinical effect analysis of Mammotome rotatory cutting in treating breast benign tumor 2015, 4 (3):  189-191.  Abstract ( 130 )   PDF (1257KB) ( 373 )   Save Abstract Objective: To investigate the clinical effect of Mammotome rotatory cutting in treating breast benign tumor. Methods: 63 cases with breast benign tumor in our hospital were selected and divided into control group, observation group A and observation group B, 21 cases in each group. The control group was given conventional surgical treatment. Observation group A was given Mammotome rotatory cutting outpatient treatment. Observation group B was given Mammotome rotatory cutting under treatment in hospital. Compared the blood loss of the operation, operation time, length of incision and variations of complications of the two groups. Results: Blood loss of the operation, operation time, length of incision, incision healing time, hospital stays, surgery costs, hospitalization costs of observation group A and B were obviously better than control group, the difference was statistically significant (P<0.05). Hospital stays, surgery costs, hospitalization costs of observation group A were better than group B, the difference was statistically significant (P<0.05). Compared the complications of the three groups, the difference was not statistically significant (P>0.05). Conclusion: Mammotome rotatory cutting in treating breast benign tumor can reduce the blood loss of the operation, shorten the operation time and incision healing time, lower the hospitalization costs and complications of the patients. References | Related Articles | Metrics

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Microcystic adnexal carcinoma：clinical and pathologic analysis and review of literature 2015, 4 (3):  192-195.  Abstract ( 150 )   PDF (1623KB) ( 490 )   Save [Abstract] Objective To investigate the clinicopathologic characteristics of microcystic adnexal carcinoma (MAC) for improving the diagnosis. Methods One case of MAC was observed for its clinical symptoms, imaging features, analysising pathological characteristics and immunohistochemical phenotypes of surgical specimens, and also reviewed of relevant literatures. Results The main clinical manifestation of this old male patient was characterized by axillary mass with pain. Chest CT was showed the soft tissue image of a slightly lower density of the mass, and unevenly consolidated by the enhancement of the group. The pathological changes of tumor cells, cell clusters and adenoid structures, are significant. AE3 / AEI, CK19 and EMA positive staining of tumor cells ware demonstrated by immunohistochemistry. Conclusions MAC is a low-grade malignancy. The operation is not easy to be completely removed, and has higher recurrence rate. It is easy to be misdiagnosed for biopsy, and depends on surgical resection specimen to defininte diagnosis. References | Related Articles | Metrics

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Advances in diagnosis and treatment of thyroid cancer based on molecular biology 2015, 4 (3):  196-200.  Abstract ( 129 )   PDF (1203KB) ( 760 )   Save The reseach on molecular biology of thyroid cancer has made substantial progress since the bigining of this century.New molecular markers emerged helps to improve diagnosis.Further understanding of the molecular markers to help the treatment of thyroid operation,postoperate treatment.Novel molecular-targeted treatments hold great promise for radioiodine-refractory and surgically inoperable thyroid caners.In this paper we discuss the molecular-based treatment strategies for thyroid cancer. References | Related Articles | Metrics

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New progress of the clinical research of polypoidal choroidal vasculopathy 2015, 4 (3):  204-207.  Abstract ( 167 )   PDF (1176KB) ( 353 )   Save Polypoidal choroidal vasculopathy (PCV) is a multiple choroid vascular diseases in colored people and so on Asian, higher incidence in our country. Indocyanine green angiography showed a polypoid expansion of choroid blood vessels is recognized a gold standard for diagnosis of PCV．Always, PCV was seen as a subtype of wet age-related macular degeneration.But with the development of medicine, the pathogenesis of PCV arises controversy. PCV is an independent disease or subtypes of age-related macular degeneration is still no unified standard, PCV clinical diagnosis, optimal treatment options and prognosis is different from wet age-related macular degeneration. In this paper, the PCV clinical characteristics, imaging examination and clinical aspects is included. Although PCV pathogenesis is unclear, we believe that through our unremitting efforts,the diagnosis and understanding of PCV pathogenesis will improve． References | Related Articles | Metrics

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Progress in the study of pulmonary rehabilitation after resection of lung cancer 2015, 4 (3):  208-211.  Abstract ( 163 )   PDF (1065KB) ( 749 )   Save Background: with the development of human life style, urbanization, industrialization, lung cancer has become the first high incidence of cancer. For the treatment of lung cancer, the current domestic and international is still to surgical resection as a first-line treatment. Progression of lung cancer surgery, from the initial open chest surgery to minimally invasive video-assisted thoracoscopic surgery (VATS) development; resection range from whole lung lobe resection changes to lobectomy, pulmonary segmental resection, wedge resection of a variety of ways. In recent years, with the treatment of pulmonary rehabilitation exercise, more and more comprehensive treatment can be used to promote the rehabilitation of patients with lung cancer surgery. Objective: To investigate the factors affecting the recovery of pulmonary function in patients with lung cancer and the intervention measures. Content: This paper reviews the factors that affect lung function recovery after surgery for lung cancer patients and the medical intervention to protect the pulmonary function after operation. Trend: there are many factors that affect the level of postoperative pulmonary function recovery, preoperative evaluation of pulmonary function, intraoperative use of low invasive surgery, postoperative active rehabilitation treatment, can give patients in the postoperative recovery of pulmonary function to play an effective support. References | Related Articles | Metrics

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Extending the role of nursing in reducing the incidence of complications in patients with cirrhosis 2015, 4 (3):  212-215.  Abstract ( 121 )   PDF (1205KB) ( 295 )   Save Abstract: Objective Discussion on reducing the incidence of complications in patients with cirrhosis of the role of extended care. Methods From 2014 in January to 2015 in January, studying in Gastroenterology of Shanghai Tongji Hospital for treatment of 80 cases of liver cirrhosis 70 years old, through randomized into experimental group and control group 40 cases, the experimental group after discharge tracking and tracing the patient regularly missionary guidance, control group treated with conventional in-hospital health education work. Analyzed at one year after the occurrence of complications in the two groups of patients. Result By extending the results of the patient care, has been in the experimental group improved referral rate within 1 year, compared with the control group was statistically significant (P <0.05); incidence of complications in patients 1 year after the experimental group decreased, compared with the control group was statistically significant (P <0.05). Conclusion Extended care can reduce the incidence of complications in patients with cirrhosis. References | Related Articles | Metrics