Abstract: Objective To investigate the effect of perioperative infusion of lidocaine on restlessness and recovery quality from general anesthesia after gynecological laparoscopic surgery. Methods Ninety patients （20-58 years old） who underwent gynecological laparoscopic surgery under general anesthesia were randomly divided into a control group and a lidocaine group, with 45 cases in each group. The lidocaine group were injected intravenously with 1 mg/kg lidocaine 10 min before anesthesia, followed by continuous intravenous pumping of lidocaine at a rate of 1 mg/（kg·h） until the end of the surgery. The control group received intravenous injection of normal saline at the same volume. After operation, propofol and remifentanil usages, language recovery time after extubation, extubation time after propofol stopped, cough score, and sedation score during extubation were recorded. Sedation score, Numeric Rating Scale （NRS） score of pain, vomiting severity and incidence were recorded at the post-anesthesia care unit （PACU）. Results Compared with the control group, the lidocaine group showed lower incidence rates of cough, moderate cough, and severe cough （P<0.05）. There was no significant difference in the sedation score between the two groups （P>0.05）. At the PACU, there were no significant differences in the NRS score and the highest pain score between the two groups （P>0.05）. There were no differences in the incidence rate of PONV and the highest PONV score between the two groups. Less propofol and remifentanil were used in the lidocaine group than in the control group. In addition, there was no statistical difference in the length of stay in PACU between the two groups. Conclusion Perioperative use of lidocaine could improve the quality of recovery from general anesthesia after gynecological laparoscopic surgery, and reduce the usage of propofol and remifentanil.

Key words: Lidocaine, Quality of recovery, Accelerated rehabilitation surgery