缝隙连接蛋白32与肝脏稳态相关性研究综述

doi:10.3969/j.issn.2095-378X.2021.04.014

Abstract

Abstract: The roles of intercellular communication in maintaining homeostasis in tissues, organs, and even individuals are of the utmost importance. Gap junction （GJ） acts as a vital medium. As a popular organ of interest, the liver is the first organ to be studied in the field of GJ. Cx32, a liver-specific connexin （Cx） constituting more than 90% of liver GJ, plays an important role in cell proliferation and differentiation, tissue functioning and homeostasis, pathophysiological changes, toxicological injury, and cell carcinogenesis. Hence, understanding the diverse changes in the expression, localization, and function of Cx32, and carrying out research on associated mechanism of action may help explore new methods for the treatment of liver diseases in the future. This paper reviewed the correlation between Cx32 and liver homeostasis.

Key words: Connexin 32, Liver homeostasis, Intercellular communication

CLC Number:

R602

XU Yan, SHI Baomin. Review on correlation between connexin 32 and liver homeostasis[J]. Surgical Research and New Technique, 2021, 10(4): 295-299.

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Review on correlation between connexin 32 and liver homeostasis

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