紫草素-季铵盐壳聚糖水凝胶复合物促进糖尿病小腿创面愈合的临床研究

doi:10.3969/j.issn.2095-378X.2026.02.002

Abstract

Abstract: Objective To investigate the efficacy and safety of shikonin （SK） solution and shikonin-quaternized chitosan hydrogel composite （SK-QPP） in the treatment of diabetic lower leg wounds. Methods Sixty patients with diabetic lower leg wounds admitted to our hospital from January to December 2025 were selected and randomly divided into an SK group, an SK-QPP group, and a control group, with 20 cases in each group. The control group received routine treatment, while the other two groups were treated with topical SK solution and SK-QPP after debridement, respectively. Wound healing rate, effective rate, healing time, and adverse reactions were compared among the three groups. Results At 1, 2 and 4 weeks of treatment, the wound healing rate rank was SK-QPP group > SK group > control group （P<0.05）. The wound healing time was （16.24±2.87） d in the SK-QPP group, （19.68±3.12） d in the SK group, and （28.53±4.21） d in the control group （P<0.05）. The effective rate was the highest in the SK-QPP group （95.0%）, followed by the SK group （85.0%） and the control group （65.0%）（P<0.05）. There were no significant differences in adverse reactions among the three groups （P>0.05）. Conclusion Both SK solution and SK-QPP can improve the healing effect of diabetic lower leg wounds, shorten the treatment course, and show good safety, and SK-QPP has better efficacy and is worthy of clinical promotion.

Key words: Shikonin, Shikonin-quaternized chitosan hydrogel composite, Diabetic wound, Wound healing, Healing rate

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References

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Clinical study on promotion of diabetic lower leg wound healing by shikonin-quaternized chitosan hydrogel composite

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