Abstract: Objective To analyze the clinical effects of laparoscopic appendectomy by observing the changes in inflammatory factors and pain after surgery in patients with acute appendicitis. Methods Using a single-group pre-post design, a total of 96 cases of acute appendicitis treated from January 2024 to December 2025 were included. All patients underwent laparoscopic appendectomy. The changes in inflammatory factor levels [white blood cell count （WBC）, C-reactive protein （CRP）, and procalcitonin （PCT）] before surgery and at 1 d and 3 d after surgery were observed, as well as the pain levels [by visual analog scale （VAS）] at 12 h, 1 d, and 3 d after surgery. Results All the 96 patients completed the surgery. The levels of inflammatory factors （WBC, CRP, PCT） on postoperative days 1 and 3 were significantly lower than those before surgery （P<0.001）, and the levels of all indicators on postoperative day 3 were significantly lower than those on postoperative day 1 （P<0.001）. The degree of pain （VAS scores） at 12 h, 1 d, and 3 d postoperatively showed a gradual downward trend, with statistically significant differences between time points （P<0.001）. Conclusion Based on single-group before-and-after observational data, laparoscopic appendectomy can effectively reduce the inflammatory response in patients with acute appendicitis and alleviate postoperative pain, providing a reference for clinical treatment.

Key words: Acute appendicitis, Laparoscopic appendectomy, Inflammatory factors, Pain level