Abstract: Objective To evaluate the accuracy and clinical application of endoscopic ultrasound guided fine needle aspiration(EUS-FNA) in diagnosis of occupying lesions in upper digestive tract and its peripheral areas．Methods Forty-six patients underwent endoscopic ultrasonagraphy and EUS-FNA between November 2011 and December 2013．The result of cytology and／or pathology was compared with that of surgical finding and follow-up study．Results EUS-FNA was successfully performed on 35patients，with a success rate of100%． The35patients with lesions in oesophagus (4 cases), stomach(26 cases), duodenalbulb(5 cases). Among them,the lesions in 29 patients (82.85%) were cytologically confirme．The lesions in10 out of15 patients (60.66%) were pathologically confirmed．Compared with the results of pathology and long-term followe-up study，the overall diagnostic accuracy of EUS-FNA in diagnosis of lesions in upper digestive tract and its peripheral areas was 85.71%(30/35). There were no complications during the procedures. Conclusion EUS-FNA is a safe, effective and accurate method for diagnosis of occupying lesions in upper digestive tract and its peripheral areas.

Key words: Endoscopic uhrasonography, Biopsy, needle