诱导性多功能干细胞在脊髓损伤干细胞治疗中的研究进展

Abstract

Abstract: Stimulated by the 2012 Nobel Prize in Physiology or Medicine awarded for Shinya Yamanaka and Sir John Gurdon,there is an increasing interest in the induced pluripotent stem (iPS) cells and reprograming technologies in medical science.While iPS cells are expected to lead a new era providing enormous opportunities in biomedical sciences in terms of cell therapies and regenerative medicine,safety-related concerns for iPS cell-based cell therapy should be resolved prior to the clinical application of iPS cells.In this review,the pre-clinical investigations of cell therapy for spinal cord injury (SCI) using neural stem progenitor cells derived from iPS cells,and their safety issues in vivo,are outlined.We also discussed the strategy for the first human trails of iPS cell-based cell therapy for SCI patients.

Key words: Neural stem/progenitor cell, Induced pluripotnet stem cell, Spinal cord injury, Transplantation

CLC Number:

R744

ZHAO Zi-jing, CHENG Li-ming. Progression of induced pluripotent stem cells for spinal cord injury as cell transplantation therapies[J]. 外科研究与新技术, 2013, 2(1): 52-58.

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Progression of induced pluripotent stem cells for spinal cord injury as cell transplantation therapies

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