Rosai-Dorfman病1例报告并文献复习

Abstract

Abstract: 【Abstract】 Object ：To investigate the clinical and pathological featu-res, diagnosis, differential diagnosis and treatment of Rosai-Dorfman dis-ease. Methods：One cases of Rosai-Dorfman disease of skin were exa-mined by tissue morphology ,immunohistochemistry and special stainin-g ,and the related liter-atures were followed up and reviewed. Results ：Skin tissue in the der-mis see more lymph and plasma cells and tissue ce-ll hyperplasia, flaky, meantime visible multinucleated giant cells (S-100 +), and phagocytosis of lymphocytes. Immunohistochemistry: CD3 (+ +), CD20 (+ +), CD79a (+ +), CD68 (+), S-100 (+), CD138 (+). Conclusion： Rosai Dorfman disease is a rare, unexplained idiopathic organization cell hyperplasia disease, it need to differential diagnosis with Langerhans cell histiocytosis,granulo-matous infection, tissue cell phagocytosis pannicul-itis,xanthogranuloma and so on. The diagnosis mainly depends on the m-orphology and immunohistochemical markers. There are many treatme-nt methods, the current views have not been unified.

Key words: 【Key words】rosai-dorfman disease, diagnosis, differential diagnosis, treatment

References

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Rosai-Dorfman disease one cases report and literature review

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